.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 6,287,594

« Back to Dashboard

Claims for Patent: 6,287,594

Title: Oral liquid compositions
Abstract:The present invention relates to novel, liquid and semi-solid pharmaceutical compositions which can be administered in liquid form or can be used for preparing capsules containing such pharmaceutical compositions. Also provided are methods of using and processes for preparing the pharmaceutical compositions of the present invention.
Inventor(s): Wilson; Edward S. (Wilmington, NC), Trespidi; Laura A. (89073 Ulm, DE), Clark; Christy M. (Southport, NC), Desai; Ashok J. (Wilmington, NC), Meyer; Glenn A. (Wrightsville Beach, NC)
Assignee:
Application Number:09/232,354
Patent Claims: 1. A pharmaceutical composition comprising a capsule filled with a composition comprising one or more pharmaceutically active agent wherein said pharmaceutically active agent is selected from the group consisting of said agents wherein at least one of said agents having at least one acid moiety, and at least one of said agents having at least one ester group or other chemically active moiety in which the terminal moiety to said ester group or other chemically active moiety is hydrolyzed or otherwise removed in situ or in vivo forming at least one acid moiety; and wherein said pharmaceutically active agent is soluble in acid at a ratio of about 3:1 (acid to solute) to about 10,000:1 (acid to solute) or a pharmaceutically acceptable salt thereof;

at least one dispersing agent selected from the group consisting of polymer-based dispersing agents and carbohydrate-based dispersing agents, wherein the ratio of said one or more pharmaceutically active agent to said at least one polymer-based dispersing agent is from about 3:1 (w/w) to about 1:50 (w/w) and wherein the ratio of said one or more pharmaceutically active agent to said at least one carbohydrate-based dispersing agent is from about 3:1 (w/w) to about 1:20 (w/w); and

at least one solubilizing agent; and, optionally,

at least one surfactant; and further optionally,

at least one plasticizing agent;

and wherein said capsule is optionally coated.

2. A pharmaceutical composition according to claim 1 wherein said capsule is selected from the group consisting of soft gelatin capsules and hard gelatin capsules.

3. A pharmaceutical composition comprising a capsule filled with a composition according to claim 1, wherein:

said at least one dispersing agent is said at least one polymer-based dispersing agent;

said at least one solubilizing agent has a concentration ranging from about zero percent to about 99 percent (w/w) of the total composition; and, optionally,

said at least one optional surfactant has a concentration ranging from about zero percent to about 10 percent (w/w) of the total composition;

said at least one optional plasticizing agent has a concentration ranging from about zero percent to about 25 percent (w/w) of the total composition;

and wherein said capsule is optionally coated.

4. A pharmaceutical composition according to claim 3 wherein said capsule is selected from the group consisting of soft gelatin capsules and hard gelatin capsules.

5. A pharmaceutical composition comprising a capsule filled with a composition according to claim 1, wherein:

said at least one dispersing agent is said at least one carbohydrate-based dispersing agent;

said at least one solubilizing agent has a concentration ranging from about zero percent to about 99 percent (w/w) of the total composition; and, optionally,

said at least one optional surfactant has a concentration ranging from about zero percent to about 10 percent (w/w) of the total composition;

said at least one optional plasticizing agent has a concentration ranging from about zero percent to about 25 percent (w/w) of the total composition;

and wherein said capsule is optionally coated.

6. A pharmaceutical composition according to claim 5 wherein said capsule is selected from the group consisting of soft gelatin capsules and hard gelatin capsules.

7. A pharmaceutical composition according to claim 3 wherein said one or more pharmaceutically active agent is selected from the group consisting of non-steroidal anti-inflammatory drugs, quinapril, fluvastatin, lovastatin, pravastatin, cervistatin, atorvastin, simvastatin, fexofenadine, cromolyn, omeprazole, gemfibrozil, ciprofibrate, ciprofloxacin, lomefloxacin, ofloxacin, carbidopa, levodopa, retinoic acid, carboprost, penicillins, beta lactams, cephalosporins, liothryonine and probenecid.

8. A pharmaceutical composition according to claim 5 wherein said one or more pharmaceutically active agent is selected from the group consisting of non-steroidal anti-inflammatory drugs, quinapril, fluvastatin, lovastatin, pravastatin, cervistatin, atorvastin, simvastatin, fexofenadine, cromolyn, omeprazole, gemfibrozil, ciprofibrate, ciprofloxacin, lomefloxacin, ofloxacin, carbidopa, levodopa, retinoic acid, carboprost, penicillins, beta lactams, cephalosporins, liothryonine and probenecid.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc