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Claims for Patent: 6,284,804

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Claims for Patent: 6,284,804

Title: Topical suspension formulations containing ciprofloxacin and dexamethasone
Abstract:Suspension formulations containing dexamethasone and ciprofloxacin are disclosed. The formulations contain a nonionic polymer, a nonionic surfactant and an ionic tonicity agent, but are physically stable and easily re-suspended. The formulations are intended for topical application to the eye, ear or nose.
Inventor(s): Singh; Onkar N. (Arlington, TX), Bhagat; Haresh G. (Fort Worth, TX)
Assignee: Alcon Universal Ltd. (Hunenberg, CH)
Application Number:09/636,563
Patent Claims: 1. A topically administrable suspension composition intended for application to the eye, ear or nose consisting essentially of

a) 0.1% (wt.) dexamethasone alcohol;

b) 0.35% (wt.) ciprofloxacin hydrochloride, monohydrate;

c) NaCI in an amount sufficient to cause the composition to have an osmolality of about 250-350 mOsm;

d) 0.2% (wt.) hydroxyethyl cellulose;

e) 0.05% (wt.) tyloxapol;

f) a buffer comprising sodium acetate and acetic acid;

g) 0.01% (wt.) benzalkonium chloride;

h) 0.01% (wt.) edetate disodium;

i) 0.6% (wt.) boric acid; and

wherein the composition has a pH of 4.5.+-.0.2.
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