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Claims for Patent: 6,284,770

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Claims for Patent: 6,284,770

Title: Medicaments for the treatment of non-constipated female irritable bowel syndrome
Abstract:This invention relates to the use of 5-HT3 receptor antagonists in the treatment of nonconstipated female IBS patients.
Inventor(s): Mangel; Allen Wayne (Chapel Hill, NC), Northcutt; Allison Ruth (Raleigh, NC)
Assignee: Glaxo Wellcome Inc. (Research Triangle Park, NC)
Application Number:09/529,050
Patent Claims: 1. A method of treatment of nonconstipated female IBS which comprises administering an effective amount of a 5-HT.sub.3 receptor antagonist or a pharmaceutically acceptable derivative thereof selected from the group consisting of granisetron, azasetron, tropisetron, ramosetron, ondansetron, lerisetron, (R) zacopride, cilansetron, itasetron, indisetron and dolasetron and pharmaceutically acceptable derivatives thereof.

2. A method of treatment of nonconstipated female IBS which comprises administering an effective amount of alosetron or a pharmaceutically acceptable derivative.

3. A method of treatment according to claim 2 wherein alosetron is in the form of its hydrochloride.

4. A method of treatment of diarrhea-predominant female IBS which comprises administering an effective amount of a 5-HT.sub.3 receptor antagonist or a pharmaceutically acceptable derivative thereof selected from the group consisting of granisetron, azasetron, tropisetron, ramosetron, ondansetron, lerisetron, (R) zacopride, cilansetron, itasetron, indisetron and dolasetron and pharmaceutically acceptable derivatives thereof.

5. A method of treatment of diarrhea-predominant female IBS which comprises administering an effective amount of alosetron or a pharmaceutically acceptable derivative thereof.

6. A method of treatment according to claim 5, wherein alosetron is in the form of its hydrochloride.

7. A method of treatment of alternating constipation/diarrhea IBS which comprises administering an effective amount of a 5-HT.sub.3 receptor antagonist or a pharmaceutically acceptable derivative thereof selected from the group consisting of granisetron, azasetron, tropisetron, ramosetron, ondansetron, lerisetron, (R) zacopride, cilansetron, itasetron, indisetron and dolasetron and pharmaceutically acceptable derivatives thereof.

8. A method of treatment of alternating constipation/diarrhea IBS which comprises administering an effective amount of alosetron or a pharmaceutically acceptable derivative thereof.

9. A method of treatment according to claim 8, wherein alosetron is in the form of its hydrochloride.
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