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|Title:||Methods of use of antimicrobial compounds against pathogenic amycoplasma bacteria|
|Abstract:||This invention relates, in part, to newly identified methods of using quinolone antibiotics, particularly a gemifloxacin compound against certain pathogenic bacteria.|
|Inventor(s):||Crabb; Donna M. (Birmingham, AL), Duffy; Lynn B. (Birmingham, AL), Searcy; Karen B. (Birmingham, AL)|
|Assignee:||SmithKline Beecham Corporation (Philadelphia, PA)|
1. A method for modulating metabolism of pathogenic Mycoplasma bacteria comprising the step of contacting pathogenic Mycoplasma bacteria with an antibacterially effective
amount of a composition comprising a gemifloxacin compound, or antibacterially effective derivatives thereof.
2. The method of claim 1 wherein said pathogenic Mycoplasma bacteria is a member of the genus Mycoplasma.
3. The method of claim 1 wherein said modulating metabolism is inhibiting growth of said bacteria.
4. The method of claim 1 wherein said modulating metabolism is killing said bacteria.
5. The method of claim 1 wherein said contacting said bacteria comprises the further step of introducing said composition into a mammal.
6. The method of claim 5 wherein said mammal is a human.
7. The method of claim 2 wherein said bacteria is selected from the group consisting of: Mycoplasma hominis and Mycoplasma fermentans.
8. The method of claim 1 wherein said bacteria is a member of the genus Ureaplasma.
9. The method of claim 8 wherein said bacteria is Ureaplasma urealyticum.
10. The method of claim 2 wherein said bacteria is selected from the group consisting of: Mycoplasma pneuoniae, Mycoplasma genitalium, and Mycoplasma penetrans.
11. The method according to claim 1, 2, 7, 8, 9 or 10 wherein the gemifloxacin compound is gemifloxacin or a pharmaceutically acceptable salt thereof.
12. The method according to claim 11 wherein the gemifloxacin compound is gemifloxacin mesylate or a hydrate thereof.
13. The method according to claim 12 wherein the gemifloxacin compound is gemifloxacin mesylate sesquihydrate.
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