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|Title:||Chronic, bolus administration of D-threo methylphenidate|
|Abstract:||Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.|
|Inventor(s):||Dariani; Maghsoud M. (Fanwood, NJ), Zeitlin; Andrew L. (Millington, NJ), Zeldis; Jerome B. (Princeton, NJ)|
|Assignee:||Celgene Corporation (Warren, NJ)|
|Patent Claims:||1. A drug dosage form comprising D-threo methylphenidate or a pharmaceutically effective salt thereof in an amount effective for once daily, bolus administration to a patient in order to engender treatment for a nervous disorder for substantially an entire day on a chronic basis.|
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