Claims for Patent: 6,251,910

Summary for Patent: 6,251,910

Title:	1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists
Abstract:	Compounds of formula having the following stereochemistry wherein R, R1, R2, R3 and R4 are as defined in the specification. The compounds are useful as P2T receptor antagonists.
Inventor(s):	Simon Guile, Anthony Ingall, Brian Springthorpe, Paul Willis
Assignee:	AstraZeneca UK Ltd
Application Number:	US09/155,023
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 6,251,910
Patent Claims:	1. A compound of formula (I) wherein: R1 is a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8-cycloalkyl or a phenyl group, each group being optionally substituted by one or more substituents selected from halogen, OR8, NR9R10, SR11 or C1-6 alkyl (itself optionally substituted by one or more halogen atoms); R2 is C1-8 alkyl optionally substituted by one or more substituents selected from the group consisting of halogen, OR8, NR9R10, SR11, or C3-8-cycloalkyl, aryl (optionally substituted by one or more C1-6 alkyl groups and/or halogen atoms), and C1-6-alkyl; or R2 is a C3-8-cycloalkyl group optionally substituted by one or more substituents selected from the group consisting of halogen, OR8, NR9R10, SR11, C1-6-alkyl and phenyl, the latter two groups being optionally substituted by one or more substituents selected from the group consisting of halogen, NO2, C(O)R8, OR8, SR11, NR12R13, 1,3-benzodioxolyl, phenyl and C1-6-alkyl the latter two groups being optionally substituted by OR8, NR9R10 or one or more halogen atoms; one of R3 and R4 hydroxy and the other is hydrogen, hydroxy or N9R10; R is a group (CR5R6)mOR7 where m is 0 or 1, R5 and R6 are independently hydrogen, C1-6 alkyl or phenyl the latter two groups being optionally substituted by halogen, and R7 is hydrogen, C1-6 alkyl or (CR5R6)nR14 where R5 and R6 are as defined above, n is 1 to 3 and R14 is COOH, OR15, NR16R17 or CONR16R17; or R is a C1-4 alkyl or C2-4 alkenyl group, each of which is substituted by one or more groups selected from the group consisting of ═S, ═O, ═NR20 and OR21 and optionally substituted by one or more groups selected from the group consisting of halogen, C1-4 alkyl, phenyl, SR21, NO2 and NR22R23 (where R21, R22 and R23 are independently hydrogen, C1-4 alkyl or phenyl; R20 is OR24 or NR25R26 where R24 is hydrogen, C1-4 alkyl or phenyl, and R25 and R26 are independently hydrogen, C1-4 alkyl, aryl, C1-6 acyl, arylsulphonyl or arylcarbonyl); R8 is hydrogen, C1-6 alkyl optionally substituted by halogen or R8 is phenyl optionally substituted by one or more substituents selected from halogen, NO2, C(O)R6, OR6, SR9, NR10R11; R9, R10 and R11 are independently hydrogen or C1-6 alkyl; R12 and R13 are independently hydrogen, C1-6 alkyl, C1-6 acyl, C1-6 alkyl sulfonyl optionally substituted by halogen, or phenyl sulfonyl optionally substituted by C1-C4 alkyl; and R15, R16 and R17 are independently hydrogen or C1-6 alkyl; or a pharmaceutically acceptable salt or solvate thereof. 2. A compound of formula (I) as defined in claim 1 having the following stereochemistry: 3. A compound according to claim 1 in which R1 is C1-4 alkyl or phenyl substituted by trifluoromethyl. 4. A compound according to claim 1 in which R2 is butyl or cyclopropyl optionally substituted by phenyl, the phenyl group itself being optionally substituted by one or more halogen, C1-6 alkyl, phenoxy or phenyl groups. 5. A compound according to claim 1 in which R3 and R4 are both hydroxy. 6. A compound according to claim 1 in which R5 and R6 are both hydrogen. 7. A compound according to claim 1 in which R is OH, CH2OH, CH2CH2OH, OCH2CH2OH, CH2OCH2C(CH3)2OH and OCH2C(CH3)2OH. 8. A compound according to claims 1 which is: [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-(1α,2α,3β,5β)]-5-[7-[(Cyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-3-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-(1α,2α,3β,5β)]-5-[7-(Butylamino)-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-3-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-(1α,2α,3β,5β)]-5-[7-Butylamino)-5-[[4-trifluoromethyl)phenyl]thio]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-3-(hydroxymethyl)-cyclopentane-1,2-diol, 2-[[[1R-(1α,2β,3β,4α)]-4-[7-(Butylamino)-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-2,3-dihydroxy-cyclopentyl]methoxy]acetic acid, 1-[[1S-[1α,2β,3β,4α(1S*,2R*)]]-2-Hydroxy-4-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-2,3-dihydroxy-cyclopentyl]-ethanone, 1-[[1S-[1α,2β,3β,4α]]-4-[7-(Butylamino)-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-2,3-dihydroxy-cyclopentyl]-2-hydroxy-ethanone, 1-[[1S-[1α,2β,3β,4α(1S*,2R*)]]-2,3-Dihydroxy-4-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentyl]-ethanone, 1-[[1S-[1α,2β,3β,4α]-4-[7-(Butylamino)-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-2,3-dihydroxy-cyclopentyl]-ethanone, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(1-Hydroxy-1-methylethyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[(2-Phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, 2-[[[1S-[1α,3β,4α(1S*,2R*)]]-3-Hydroxy-4-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentyl]oxy]acetic acid, 2-[[[1S-[1α,2β,4α(1S*,2R*)]]-2-Hydroxy-4-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentyl]oxy]acetic acid, 2-[[[1S-(1α,2β,3β,4α)]-4-[7-(Butylamino)-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-2,3-dihydroxy-cyclopentyl]oxy]acetic acid, 2-[[[1S-(1α,2β,3β,4α)]-4-[7-(Butylamino)-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-2,3-dihydroxycyclopentyl]oxy]acetamide, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[[5-Methylthio)-7-[(2-phenylcyclopropyl)amino]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[5-[(Methylethyl)thio]-7-[(2-phenylcyclopropyl)amino]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(4-Fluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(4-Methoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(4-Methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(4-Chlorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, 2-[[[1S-[1α,2β,3β,4α(1S*,2R*)]]-2,3-Dihydroxy-4-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentyl]oxy]-acetamide, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3-Methoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3-Methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3-Chlorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3-Nitrophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[(1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(4-Phenoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3-Phenoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1a,2b,3b,4a(1S*,2R*)]-4-[7-[[2-(3-Aminophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-(1a,2a,3b,5b)]-3-[7-(Butylamino)-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(3-hydroxypropoxy)-cyclopentane-1,2-diol, [1S-[1a,2a,3b,5b(1S*,2R*)]]-3-(2-Hydroxyethoxy)-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1a,2a,3b,5b(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[[2-(4-methoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1R-[1a,2a,3b(1S*,2R*),5b]]-5-[7-[[(2-(4-Chlorophenyl)cyclopropyl)]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-3-(hydroxymethyl)-cyclopentane-1,2,-diol, [1R-[1α,2α,3β(1S*,2R*),5β]]-3-[7-[[2-(3-Chlorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Methoxymethyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[5-(methylthio)-7-[(2-phenylcyclopropyl)amino]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-[(1-methylethyl)thio]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-(prop-2-enylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[5-(4-methylphenylthio)-7-[(2-phenylcyclopropyl)amino]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[[2-(4-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,(R*),5β(1S*,2R*)]]-3-(1-Hydroxyethyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,(S*),5β(1S*,2R*)]]-3-(1-Hydroxyethyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[5-(Ethylthio)-7-[[2-phenylcyclopropyl]amino]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-[(1,1′-Biphenyl)-4-yl]cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1R-(1α,2α,3β,5β)]-3-[7-(Butylamino)-5-(cyclopentylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-[4-(trifluoromethyl)-phenylthio]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[[2-(4-phenoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1S*,2R*),5β]]-3-[7-[[2-(2-Chlorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethoxymethyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2diol, [1R-[1α,2β,3β,4α(1R*,2S*)]]-3-Hydroxy-2-methoxy-4-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentanemethanol, [1R-[1α,2β,3β,4α(1R*,2S*)]]-2-Hydroxy-3-methoxy-4-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentanemethanol, [1S-[1α,2α,3β(E),5β(1S*,2R*)]]-3-(3-Hydroxy-prop-1-enyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(3-Hydroxypropyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, 1-[[1S-[1α,2β,3β,4α(1S*,2R*)]]-2,3-Dihydroxy-4-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentyl]-2-methoxyethanone, [1S-(1α,2α,3β,5β)]-3-(Hydroxymethyl)-5-[7-[[(trans)-2-(3,4-methylenedioxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[[2-(3-methoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[[2-(4-hydroxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[[2-(3-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[[2-(3-phenoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(4-Fluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[[2-(3-nitrophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1R-[1α,2α,3β,5β(1R*,2S*)]]-3-[7-[[2-(3-Aminophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3,5-Dimethoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-[(2-Hydroxy-2,2-dimethyl)ethoxy]-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-1,2-cyclopentanediol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[[2-[4-(1-methylethyloxy)phenyl]cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(3-Hydroxypropoxy)-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-1,2-cyclopentanediol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1R-[1α,2α,3β(1S*,2R*),5β]]-3-[7-[[2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3,5-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-[[1,1′-Biphenyl]-3-yl]cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-[1,1′-Biphenyl]-3-yl]cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, N-Ethyl-[[[1S-[1α,2β,3β,4α(1S*,2R*)]]-2,3-dihydroxy-4-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentyl]oxy]-acetamide, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3-Methoxy-4-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(4-N,N-Dimethylaminophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-hydroxymethyl-cyclopentane-1,2diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3-Fluoro-4-methoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[[2-(4-methoxy-3-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3,4-Dichlorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-3-(hydroxymethyl)-cyclopentane-1,2-diol, 1S-[1α,2α,3β,5β(1S*,2R*)]-3-[(2-Amino)ethoxy]-5-[7-(2-phenylcyclopropyl)amino]-5-propylthio-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1R-(1α,2α,3β(1R*,2S*),5β)]-3-[7-[[2-(3,4-Dimethylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3,4-Dimethylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1R-(1α,2α,3β,5β)]-3-[7-(Cyclopropylamino)-5-[[4-(trifluoromethyl)phenyl]thio]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3,5-Dichlorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1R-[1α(1S*,2R*),2β,3β,4α]]-N-[3-[2-[[3-(2,3,4-Trihydroxy-cyclopentyl)-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl]amino]cyclopropyl]phenyl]-methanesulfonamide, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3,4-Dimethoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(4-Methoxy-3-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1R-[1α(1S*,2R*),2β,3β,4α]]-N-[3-[2-[[3-(2,3,4-Trihydroxy-cyclopentyl)-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl]amino]cyclopropyl]phenyl]-acetamide, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[(2-(3,4-Dichlorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(4-Chloro-3-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(trans)]]-4-[7-[[2-(Phenylmethyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(4-Chloro-3-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3-Dimethylaminophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3-Fluoro-4-methoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3,5-Dimethylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3-Chloro-4-methoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1R-[1α,2α,3β(1R*,2S *),5β]]-3-[7-[[2-(3-Chloro-4-methoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1R-[1α(1S*,2R*),2β,3β,4α]]-N-[3-[[2-[3-[2,3-Dihydroxy-4-(hydroxymethyl)cyclopentyl]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl]amino]cyclopropyl]phenyl]-methanesulphonamide, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3,5-Dimethoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3-Fluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, [1R-[1α(1S*,2R*),2β,3β,4α]]-N-[[3-[2-[3-(2,3-Dihydroxy-4-hydroxymethylcyclopentyl)-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl]amino]cyclopropyl]phenyl]-acetamide, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3,5-Dichlorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1R-[1α(1S*,2R*),2β,3β,4α]]-N-[3-[2-[[3-[2,3-Dihydroxy-4-(2-hydroxyethyl)-cyclopentyl]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl]amino]cyclopropyl]phenyl]-methanesulfonamide, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[7-[[2-(4-phenoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[7-[[2-(3-phenoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(4-Bromophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-[(1,1′-Biphenyl)-2-yl]cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-[(1,1′-Biphenyl)-3-yl]cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3,5-Dichlorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3,4-Dichlorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3-Chloro-4-methoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3,4-Dimethoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α(1S*,2R*),2β,3β,4α]]-N-[3-[2-[[3-[2,3-Dihydroxy-4-(2-hydroxyethyl)-cyclopentyl]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl]amino]cyclopropyl]phenyl]-acetamide, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3-Chloro-4-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(4-Chloro-4-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(4-Fluoro-3-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[7-[[2-(3-nitrophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[7-[[2-(4-methoxy-3-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[7-[[2-(3-methoxy-4-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(4-N,N-Dimethylaminophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3,5-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3-Chlorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[7-[[2-(2-methoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[7-[[2-(4-methoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[7-[[2-(3-methoxyphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3,5-Dimethylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(4-Fluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3-Fluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[7-[[2-(2-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[7-[[2-(3-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[7-[[2-(4-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[7-(cyclopropylamino)-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxy-2-methylpropoxymethyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(3-Chloro-4-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1R-[1α(1S*,2R*),2β,3β,4α]]-4-[2-[[3-(2,3,4-Trihydroxycyclopentyl)-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl]amino]cyclopropyl]phenylsulfonamide, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[5-(Butylthio)-7-[(2-phenylcyclopropyl)amino]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(hydroxymethyl)-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[5-(pentylthio)-7-[(2-phenylcyclopropyl)amino]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[(2-phenylcyclopropyl)amino]-5-(prop-2-enylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[[2-(3,5-dimethylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(2-Hydroxyethyl)-5-[5-(methylthio)-7-[(2-phenylcyclopropyl)amino]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[5-(Butylthio)-7-[(2-phenylcyclopropyl)amino]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethyl)-cyclopentane-1,2-diol, [1R-[1α,2α,3β(1R*,2S*),5β]]-3-[7-[[2-(4-chlorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-[(2-hydroxy)ethoxy]-cyclopentane-1,2-diol, [1S-[1α,2α,3β,5β(1S*,2R*)]]-3-(Hydroxymethyl)-5-[7-[(2-phenycyclopropyl)amino]-5-[(3,3,3-trifluoropropyl)thio]-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, [1S-[1α,2β,3β,4α(1S*,2R*)]]-4-[7-[[2-(3-Chloro-4-methylphenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2,3-triol, or pharmaceutically acceptable salts or solvates thereof. 9. A pharmaceutical composition comprising a compound according to claim 1 in combination with a pharmaceutically acceptable diluent, adjuvent or carrier. 10. A method of treatment of unstable angina, coronary angioplasty (PTCA), perithrombolysis, primary arterial thrombotic complications of atherosclerosis, arterial complications due to interventions in atherosclerotic disease, or thrombotic complications of surgical or mechanical damage, which comprises administering to a patient in need of such treatment a therapeutically effective amount of a compound according to claim 1. 11. A process for the preparation of a compound of formula (I) as defined in claim 1 which comprises; (a) reacting a compound of formula (II): where R, R1, R3 and R4 are as defined in formula (I) or are protected derivatives thereof, and L is a leaving group with a compound of formula (III): R2NH2 (III) where R2 is as defined in formula (I) or is a protected derivative thereof, or (b) reacting a compound of formula (IV): in which R1 and R2 are as defined in formula (I) or are protected derivatives thereof and P1 and P2 are protecting groups or hydrogen, with a suitable reagent to introduce a substituent R, or, for compounds where m is 0: (c) hydroxylation of a compound of formula (V): where R1, R2 and R7 are as defined in formula (I) or are protected derivatives thereof, and optionally thereafter (a), (b) or (c) and in any order: removing any protecting groups forming a pharmaceutically acceptable salt or solvate. 12. A method of treatment of a condition selected from the group consisting of myocardial infarction, thrombotic stroke, transient ischaemic attack, peripheral vascular disease and angina, which comprises administering to a patient in need of such treatment an effective amount of a compound according to claim 1. 13. A method according to claim 12, wherein the condition is angina. 14. A method according to claim 10, wherein said interventions are selected from the group consisting of angioplasty, endarterectomy, stent placement, coronary surgery and other vascular graft surgery.