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|Title:||Method of peritoneal dialysis using glucose polymer solutions|
|Abstract:||There is described polysaccharides of high molecular weight for use in peritoneal dialysis. The polysaccharides are capable of dialysing human serum for long periods of time without causing damage to the peritoneum and are also capable of preventing loss of polymer from the peritoneum to the serum. There is also described a method of making the polysaccharides and pharmaceutical formulations containing them.|
|Inventor(s):||Alsop; Ranulph Michael (Alderley Edge, GB), Forrester; Raymond Brian (Sandbach, GB), Manning; David John (Congleton, GB)|
|Assignee:||M L Laboratories plc (London, GB)|
1. A method of treatment of a human requiring dialysis of the serum by use of an aqueous solution of a physiologically acceptable mixture of glucose polymers derived from the hydrolysis
of starch, wherein at least 50% by weight of said mixture comprises polymers having molecular weights in the range of from 5,000 to 30,000, and wherein said mixture has a weight average molecular weight of from 5,000 to 50,000, and a number average
molecular weight of from 2,890 to 8,000.
2. A method of treatment in accordance with claim 1 wherein up to 20% by weight of the polymers in the mixture have a molecular weight of from 800 to 10,000.
3. A method of treatment in accordance with claim 1 wherein the mixture contains less than 5% by weight of glucose polymers with molecular weight greater than 100,000.
4. A method of claim 1 wherein the aqueous solution further comprises amino acids.
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