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Claims for Patent: 6,239,173

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Claims for Patent: 6,239,173

Title: 3-phenyl-4-(4(methylsulfonyl)phenyl)-2-(5H)-furanone as a cox-2 inhibitor
Abstract:The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
Inventor(s): Wang; Zhaoyin (Pierrefond, CA), Therien; Michel (Laval, CA)
Assignee: Merck Frosst Canada Inc./Merck Frosst Canada & Co. (Kirkland, CA)
Application Number:09/443,000
Patent Claims: 1. A compound which is 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone.

2. A method of treating an inflammatory disease in a human patient in need of such treatment comprising administering a non-toxic therapeutically effective amount of 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone and a pharmaceutically acceptable carrier.

3. A method of treating a cyclooxygenase-2 mediated disease in a human patient in need of such treatment comprising administering a non-toxic therapeutically effective amount of 3-phenyl-4-(4-(methylsulfonylphenyl)-2-(5H)-furanone and a pharmaceutically acceptable carrier.

4. A method according to claim 2 of treating arthritis in a human patient in need of such treatment comprising administering a non-toxic therapeutically effect amount of 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone and a pharmaceutically acceptable carrier.

5. A method according to claim 2 of treating rheumatoid arthritis in a human patient in need of such treatment comprising administering a non-toxic therapeutically effective amount of 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone and a pharmaceutically acceptable carrier.

6. A method according to claim 2 of treating osteoarthritis in a human patient in need of such treatment comprising administering a non-toxic therapeutically effective amount of 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone and a pharmaceutically acceptable carrier.

7. A method according to claim 2 of treating pain in a human patient in need of such treatment comprising administering a non-toxic therapeutically effective amount of 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone and a pharmaceutically acceptable carrier.

8. A method according to claim 2 of treating fever in a human patient in need of such treatment comprising administering a non-toxic therapeutically effect amount of 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone and a pharmaceutically acceptable carrier.

9. A method according to claim 2 of treating dysmenorrhea in a human patient in need of such treatment comprising administering a non-toxic therapeutically effective amount of 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone and a pharmaceutically acceptable carrier.

10. A pharmaceutical compostion comprising 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone and a pharmaceutically acceptable carrier.
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