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Claims for Patent: 6,235,756

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Claims for Patent: 6,235,756

Title: Methods and compositions for inhibition of angiogenesis by thalidomide
Abstract:The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.
Inventor(s): D'Amato; Robert (Lancaster, PA)
Assignee: The Children's Medical Center Corporation (Boston, MA)
Application Number:08/918,610
Patent Claims: 1. A method of treating undesired angiogenesis in a human or animal having a tumor comprising administering to the human or animal in need thereof an angiogenesis inhibiting amount of thalidomide.

2. The method of claim 1 wherein the tumor is Kaposi's sarcoma.

3. The method of claim 1 wherein the tumor is hemangioma.

4. The method of claim 1 wherein the tumor is a solid tumor.

5. The method of claim 1 wherein the tumor is a blood borne tumors.

6. The method of claim 1 wherein the tumor is rhabdomyosarcoma.

7. The method of claim 1 wherein the tumor is retinoblastoma.

8. The method of claim 1 wherein the tumor is Ewing's sarcoma.

9. The method of claim 1 wherein the tumor is neuroblastoma.

10. The method of claim 1 wherein the tumor is osteosarcoma.

11. The method of claim 1 wherein the tumor is neurofibroma.

12. The method of claim 1 wherein the tumor is pyogenic granulomas.

13. The method of claim 1 wherein the tumor is breast cancer.

14. The method of claim 1 wherein the amount administered is between approximately 0.1 and approximately 300 mg/kg/day.

15. The method of claim 14 wherein the amount administered is between approximately 0.5 and approximately 50 mg/kg/day.

16. The method of claim 15 wherein the amount administered is between approximately 1 and approximately 10 mg/kg/day.

17. The method of claim 1 wherein the thalidomide is administered in the form of a tablet.

18. The method of claim 1 wherein the thalidomide is administered in the form of a capsule.

19. The method of claim 1 wherein the thalidomide is administered in the form of a lozenge, a cachet, a solution, a suspension, an emulsion, a powder, an aerosol, a suppository, a spray, a pastille, an ointment, a cream, a paste, a foam, a gel, a tamport, or a pessary.

20. The method of claim 1, 4, 5, or 14 wherein the administration is oral.

21. The method of claim 1, 4, 5, or 14 wherein the administration is sublingual, buccal, rectal, vaginal, or nasal.

22. The method of claim 1, 4, 5, or 14 wherein the administration is parenteral.

23. The method of claim 1, 4, 5, or 14 wherein the administration is transdermal or topical.

24. A method of treating undesired angiogenesis in a human or animal having leukemia comprising administering to the human or animal in need thereof an angiogenesis inhibiting amount of thalidomide.
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