|Title:||Entric-coated pharmaceutical compositions|
|Abstract:||This invention provides a pharmaceutical composition comprising a mycophenolate salt, the composition being adapted to release mycophenolate in the upper part of the intestinal tract.|
|Inventor(s):||Haeberlin; Barbara (Riehen, CH), Mak; Ching-Pong (Therwil, CH), Meinzer; Armin (Buggingen, DE), Vonderscher; Jacky (Riedisheim, FR)|
|Assignee:||Novartis AG (Basel, CH)|
1. A pharmaceutical composition comprising a mycophenolate salt, the composition being formulated to disintegrate selectively in the intestinal tract to release mycophenolate
2. A method of immunosuppressing a subject which comprises administering a therapeutically effective amount of a composition of claim 1 to a subject in need of such immunosuppression, optionally with the simultaneous or separate administration another immunosuppressant, wherein the composition has an enteric coating.
3. A composition containing a composition of claim 1 and another immunosuppressant for simultaneous, sequential or separate administration, wherein the composition has an enteric coating.
4. A composition according to claim 1 wherein the salt is the mono-sodium salt.
5. A composition according to claim 1 wherein said composition further comprises another immunosuppressant.
6. The pharmaceutical composition of claim 1 wherein said composition has an enteric coating and is suitable as an immunosuppressant medicament.
7. The pharmaceutical composition of claim 6 wherein said composition further comprises a second immunosuppressant.
8. The pharmaceutical composition of claim 7 wherein said second immunosuppressant is cyclosporin.
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