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Claims for Patent: 6,169,181

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Claims for Patent: 6,169,181

Title: Compounds useful to treat retroviral infections
Abstract:The present invention relates to compounds of formula I and II which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus. ##STR1## wherein R.sub.10 and R.sub.20 taken together are: ##STR2##
Inventor(s): Romines; Karen Rene (Paw Paw, MI), Bundy; Gordon L. (Portage, MI), Schwartz; Theresa M. (Kalamazoo, MI), Tommasi; Ruben A. (Whitehouse Station, NJ), Strohbach; Joseph W. (Mendon, MI), Turner; Steven Ronald (Kalamazoo, MI), Thaisrivongs; Suvit (Kalamazoo, MI), Aristoff; Paul Adrian (Kalamazoo, MI), Johnson; Paul D. (Portage, MI), Skulnick; Harvey Irving (Kalamazoo, MI), Skaletzky; Louis L. (Kalamazoo, MI), Anderson; David John (Kalamazoo, MI), Morris; Joel (Kalamazoo, MI), Gammill; Ronald B. (Portage, MI), Luke; George P. (Lexington, MA)
Assignee: Pharmacia & Upjohn Company (Kalamazoo, MI)
Application Number:09/188,998
Patent Claims: 1. A compound of the formula I ##STR135##

wherein R.sub.1 is H--;

wherein R.sub.2 is

a) C.sub.3 -C.sub.5 alkyl,

b) phenyl-(CH.sub.2).sub.2 --,

c) het-SO.sub.2 NH--(CH.sub.2).sub.2 --,

d) cyclopropyl-(CH.sub.2).sub.2 --,

e) F-phenyl-(CH.sub.2).sub.2 --,

f) het-SO.sub.2 NH-phenyl-, or

g) F.sub.3 C--(CH.sub.2).sub.2 --;

or wherein R.sub.1 and R.sub.2 taken together are a double bond;

wherein R.sub.3 is the moiety of formula X ##STR136##

wherein R.sub.4 is

a) phenyl,

b) het,

c) cyclopropyl,

d) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --,

e) het-SO.sub.2 NH--,

f) Br--,

g) N.sub.3 --, or

h) HO.sub.3 S(CH.sub.2).sub.2 --N(CH.sub.3)--C(O)--(CH.sub.2).sub.6 --C(O)--NH--;

wherein R.sub.5 is --H;

wherein R.sub.6 is

a) R.sub.4 --(CH.sub.2).sub.n --CH(R.sub.8)--,

b) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --CH.sub.2 --,

c) C.sub.3 -C.sub.5 alkyl,

d) phenyl-(CH.sub.2).sub.2 --,

e) het-SO.sub.2 NH--(CH.sub.2).sub.2 --,

f) (HOCH.sub.2).sub.3 C--NH--C(O)--NH--(CH.sub.2).sub.3 --,

g) (HO.sub.2 C)(H.sub.2 N)CH--(CH.sub.2).sub.2 --C(O)--NH--(CH.sub.2).sub.3 --,

h) piperazin-1-yl-C(O)--NH--(CH.sub.2).sub.3,

i) HO.sub.3 S(CH.sub.2).sub.2 --N(CH.sub.3)--C(O)--(CH.sub.2).sub.6 --C(O)--NH--(CH.sub.2).sub.3 --,

j) cyclopropyl-(CH.sub.2).sub.2 --,

k) F-phenyl-(CH.sub.2).sub.2 --,

l) het-SO.sub.2 NH-phenyl, or

m) F.sub.3 C--(CH.sub.2).sub.2 --;

wherein n is zero (0), one (1) or two (2);

wherein R.sub.7 is

a) cyclopropyl,

b) CH.sub.3 --CH.sub.2 --, or

c) t-butyl;

wherein R.sub.8 is

a) --CH.sub.2 --CH.sub.3, or

b) --CH.sub.2 -cyclopropyl;

wherein R.sub.9 is

a) --NR.sub.12 SO.sub.2 -het,

b) --NR.sub.12 SO.sub.2 -phenyl substituted by zero (0) or one (1) R.sub.11,

c) --CH.sub.2 --SO.sub.2 -phenyl substituted by zero (0) or one (1) R.sub.1 1, or

d) --CH.sub.2 --SO.sub.2 -het; wherein het is pyridinyl, imidazolyl, benzimidazolyl, quinolinyl, pyrimidinyl, pyrazinyl, pyrazolyl, thiazolyl, purinyl, tetrahydropyranyl or quinazolinyl; substituted by zero (0) or one (1) R.sub.10 ;

wherein R.sub.10 is

a) --CH.sub.3,

b) --CN,

c) --OH,

d) --C(O)OC.sub.2 H.sub.5,

e) --CF.sub.3,

f) --NH.sub.2, or

g) --C(O)--NH.sub.2 ;

wherein R.sub.11 is

a) --CN,

b) --F,

c) --OH, or

d) --NO.sub.2 ;

wherein R.sub.12 is

a) --H, or

b) --CH.sub.3 ;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 of the formula I ##STR137##

wherein R.sub.1 is H--;

wherein R.sub.2 is

a) C.sub.3 -C.sub.5 alkyl,

b) phenyl-(CH.sub.2).sub.2 --, or

c) het-SO.sub.2 NH--(CH.sub.2).sub.2 --;

or wherein R.sub.1 and R.sub.2 taken together are a double bond;

wherein R.sub.3 is the moiety of formula X ##STR138##

wherein R.sub.4 is

a) phenyl,

b) het,

c) cyclopropyl,

d) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --,

e) het-SO.sub.2 NH--,

f) Br--,

g) N.sub.3 --, or

h) HO.sub.3 S(CH.sub.2).sub.2 --N(CH.sub.3)--C(O)--(CH.sub.2).sub.6 --C(O)--NH--;

wherein R.sub.5 is --H;

wherein R.sub.6 is

a) R.sub.4 --(CH.sub.2).sub.n --CH(R.sub.8)--,

b) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --CH.sub.2 --,

c) C.sub.3 -C.sub.5 alkyl,

d) phenyl-(CH.sub.2).sub.2 --,

e) het-SO.sub.2 NH--(CH.sub.2).sub.2 --,

f) (HOCH.sub.2).sub.3 C--NH--C(O)--NH--(CH.sub.2).sub.3 --,

g) (HO.sub.2 C)(H.sub.2 N)CH--(CH.sub.2).sub.2 --C(O)--NH--(CH.sub.2).sub.3 --,

h) piperazin-1-yl-C(O)--NH--(CH.sub.2).sub.3, or

i) HO.sub.3 S(CH.sub.2).sub.2 --N(CH.sub.3)--C(O)--(CH.sub.2).sub.6 --C(O)--NH--(CH.sub.2).sub.3 --;

wherein n is zero (0), one (1) or two (2);

wherein R.sub.7 is

a) cyclopropyl,

b) CH.sub.3 --CH.sub.2 --, or

c) t-butyl;

wherein R.sub.8 is

a) --CH.sub.2 --CH.sub.3, or

b) --CH.sub.2 -cyclopropyl;

wherein R.sub.9 is

a) --NR.sub.12 SO.sub.2 -het,

b) --NR.sub.12 SO.sub.2 -phenyl substituted by zero (0) or one (1) R.sub.11,

c) --CH.sub.2 -SO.sub.2 -phenyl substituted by zero (0) or one (1) R.sub.11, or

d) --CH.sub.2 --SO.sub.2 -het;

wherein het is pyridinyl, imidazolyl, benzimidazolyl, quinolinyl, pyrimidinyl, pyrazinyl, pyrazolyl, thiazolyl, purinyl, tetrahydropyranyl or quinazolinyl; substituted by zero (0) or one (1) R.sub.10 ;

wherein R.sub.10 is

a) --CH.sub.3,

b) --CN,

c) --OH, or

d) --C(O)OC.sub.2 H.sub.5 ;

wherein R.sub.11 is

a) --CN,

b) --F,

c) --OH, or

d) --NO.sub.2 ;

wherein R.sub.12 is

a) --H, or

b) --CH.sub.3 ;

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 2 wherein het is the following, substituted by zero (0) or one (1) R.sub.10,

a) 2-pyridinyl,

b) imidazol-2-yl,

c) imidazol-4-yl,

d) benzimidazol-2-yl,

e) quinolin-8-yl,

f) quinolin-2-yl,

g) pyrimidin-2-yl,

h) quinazolin-2-yl,

i) purin-6-yl,

j) thiazol-2-yl,

k) thiazol-4-yl,

l) 2-pyrazolyl,

m) 2-pyrazinyl,

n) tetrahydropyran-4-yl, or

o) tetrahydropyran-3-yl.

4. The compound of claim 3 of the formula I ##STR139##

wherein R.sub.1 is H--;

wherein R.sub.2 is

a) H.sub.3 C--(CH.sub.2).sub.2 --,

b) phenyl-(CH.sub.2).sub.2 --,

c) (CH.sub.3).sub.2 CH--CH.sub.2, or

d) pentyl;

or wherein R.sub.1 and R.sub.2 taken together are a double bond;

wherein R.sub.3 is the moiety of formula X ##STR140##

wherein R.sub.4 is

a) phenyl,

b) het,

c) cyclopropyl,

d) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --,

e) het-SO.sub.2 NH--,

f) Br--,

g) N.sub.3 --, or

h) HO.sub.3 S(CH.sub.2).sub.2 --N(CH.sub.3)--C(O)--(CH.sub.2).sub.6 --C(O)--NH--;

wherein R.sub.5 is --H;

wherein R.sub.6 is

a) R.sub.4 --(CH.sub.2).sub.n --CH(R.sub.8)--,

b) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --CH.sub.2 --,

c) H.sub.3 C--(CH.sub.2).sub.2 --,

d) phenyl-(CH.sub.2).sub.2 --,

e) (CH.sub.3).sub.2 CH--CH.sub.2 --, or

f) pentyl;

wherein n is zero (0), one (1) or two (2);

wherein R.sub.7 is

a) cyclopropyl, or

b) CH.sub.3 --CH.sub.2 --;

wherein R.sub.8 is

a) --CH.sub.2 --CH.sub.3, or

b) --CH.sub.2 -cyclopropyl;

wherein R.sub.9 is

a) --NHSO.sub.2 -het, or

b) --NHSO.sub.2 -phenyl substituted by zero (0) or one (1) R.sub.11 ;

wherein het is the following, substituted by zero (0) or one (1) R.sub.10,

a) 2-pyridinyl,

b) imidazol-2-yl,

c) imidazol-4-yl,

d) quinolin-8-yl,

e) tetrahydropyran-4-yl,

f) tetrahydropyran-3-yl, or

g) benzimidazol-2-yl;

wherein R.sub.10 is

a) --CH.sub.3 ;

wherein R.sub.11 is

a) --CN,

b) --F or

c) --NO.sub.2 ;

or a pharmaceutically acceptable salt thereof.

5. The compound of claim 4 of the formula VI ##STR141##

wherein R.sub.2 is

a) H.sub.3 C--(CH.sub.2).sub.2 --,

b) phenyl-(CH.sub.2).sub.2 --,

c) (CH.sub.3).sub.2 CH--CH.sub.2 --, or

d) pentyl;

wherein R.sub.3 is the moiety of formula X ##STR142##

wherein R.sub.6 is

a) H.sub.3 C--(CH.sub.2).sub.2 --,

b) phenyl-(CH.sub.2).sub.2 --,

c) (CH.sub.3).sub.2 CH--CH.sub.2 --, or

d) pentyl;

wherein R.sub.7 is

a) CH.sub.3 --CH.sub.2 --, or

b) cyclopropyl;

wherein R.sub.9 is

a) --NHSO.sub.2 -phenyl substituted by one (1) R.sub.11, or

b) --NHSO.sub.2 -het;

wherein het is the following, substituted by zero (0) or one (1) R.sub.10,

a) imidazol-4-yl, or

b) quinolin-8-yl;

wherein R.sub.10 is --CH.sub.3 ;

wherein R.sub.11 is

a) --CN, or

b) --F.

6. The compound of claim 4 of the formula VII ##STR143##

wherein R.sub.3 is the moiety of formula X ##STR144##

wherein R.sub.4 is

a) phenyl,

b) het,

c) cyclopropyl,

d) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --,

e) het-SO.sub.2 NH--,

f) Br--,

g) N.sub.3 --, or

h) HO.sub.3 S(CH.sub.2).sub.2 --N(CH.sub.3)--C(O)--(CH.sub.2).sub.6 --C(O)--NH--;

wherein R.sub.6 is

a) R.sub.4 --(CH.sub.2).sub.n --CH(R,)--, or

b) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --CH.sub.2 --;

wherein R.sub.7 is cyclopropyl;

wherein R.sub.8 is

a) --CH.sub.2 --CH.sub.3, or

b) --CH.sub.2 -cyclopropyl;

wherein R.sub.9 is

a) --NHSO.sub.2 -het, or

b) --NHSO.sub.2 -phenyl substituted by one (1) R.sub.11 ;

wherein n is zero (0), one (1) or two (2);

wherein het is the following, substituted by zero (0) or one (1) R.sub.10,

a) imidazol-4-yl,

b) imidazol-2-yl,

c) quinolin-8-yl,

d) tetrahydropyran-3-yl,

e) tetrahydropyran-4-yl,

f) 2-pyridinyl, or

g) benzimidazol-2-yl;

wherein R.sub.10 is --CH.sub.3 ;

wherein R.sub.11 is

a) --NO.sub.2,

b) --F, or

c) --CN;

or a pharmaceutically acceptable salt thereof.

7. The compound of claim 2 selected from the group consisting of:

3-[cyclopropyl[3-[(4-cyanophenylsulfonyl)methyl]phenyl]methyl]-4-hydroxy-6- (2-phenylethyl)-6-(1-propyl)-5,6-dihydro-2H-pyran-2-one;

3-[cyclopropyl[3-[(2-pyridinylsulfonyl)methyl]phenyl]methyl]-4-hydroxy-6-(2 -phenylethyl)-6-(1-propyl)-5,6-dihydro-2H-pyran-2-one;

3-[cyclopropyl[3-[(1-methyl-4-imidazolylsulfonyl)methyl]phenyl]methyl]-4-hy droxy-6-(2-phenylethyl)-6-(1-propyl)-5,6-dihydro-2H-pyran-2-one;

3-[cyclopropyl[3-[(5-cyano-2-pyridinylsulfonyl)methyl]phenyl]methyl]-4-hydr oxy-6-(2-phenylethyl)-6-(1-propyl)-5,6-dihydro-2H-pyran-2-one;

3-[cyclopropyl[3-[(2-benzimidazolylsulfonyl)methyl]phenyl]methyl]-4-hydroxy -6-(2-phenylethyl)-6-(1-propyl)-5,6-dihydro-2H-pyran-2-one;

3-[cyclopropyl[3-[(2-quinolinylsulfonyl)methyl]phenyl]methyl]-4-hydroxy-6-( 2-phenylethyl)-6-(1-propyl)-5,6-dihydro-2H-pyran-2-one;

4-Cyano-N-[3-[1-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran- 3-yl)-propyl]-phenyl]-benzenesulfonamide;

N-[3-[1-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-[1-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-8-quinolinesulfonamide;

N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-propyl]-ph enyl]-8-quinolinesulfonamide;

N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5 ,6-dihydro-2H-pyran-3-yl)-propyl]-phenyl]-1-methyl-1H-imidazolesulfonamide ;

4-Fluoro-N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-p ropyl]-phenyl]-benzenesulfonamide;

4-Cyano-N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-benzenesulfonamide;

N-[3-[1-(4-hydroxy-6,6-diisobutyl-2-oxo-5,6-dihydro-2H-pyran-3-yl)-propyl]- phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-cyclo-prop ylmethyl]-phenyl]-1-methyl-1H-imidazolesulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-cyclo-prop ylmethyl]-phenyl]-8-quinolinesulfonamide;

4-Cyano-N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-cy clopropylmethyl]-phenyl]-benzenesulfonamide;

4-Fluoro-N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-c yclopropylmethyl]-phenyl]-benzenesulfonamide;

(R or S)-N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-propyl ]-phenyl]-8-quinolinesulfonamide;

(R or S)-N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-propyl ]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

(S or R)-N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-propyl ]-phenyl]-8-quinolinesulfonamide;

(S or R)-N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-propyl ]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

(R or S)-N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-cyclop ropylmethyl]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

(S or R)-N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-cyclop ropylmethyl]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

4-Cyano-N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran- 3-yl)-cyclopropylmethyl]-phenyl]-benzenesulfonamide;

4-Fluoro-N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran -3-yl)-cyclopropylmethyl]-phenyl]-benzenesulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-cy clopropylmethyl]-phenyl]-8-quinolinesulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-cy clopropylmethyl]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-cyclopr opylmethyl]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipentyl-5,6-dihydro-2H-pyran-3-yl)-propyl]-ph enyl]-1-methyl-1H-imidazole-4-sulfonamide;

4-Cyano-N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipentyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-benzenesulfonamide;

N-[3-[1(R or S)-(6(R or S)-4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-[1(R or S)-(6(S or R)-4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-[1(S or R)-(6(R or S)-4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-[1(S or R)-(6(S or R)-4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-[t-Butyl-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3- yl)-methyl]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

4-Cyano-N-[3-[t-butyl-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H- pyran-3-yl)-methyl]-phenyl]-benzenesulfonamide;

4-Fluoro-N-[3-[t-butyl-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H -pyran-3-yl)-methyl]-phenyl]-benzenesulfonamide;

N-[3-[t-Butyl-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3- yl)-methyl]-phenyl]-8-quinolinesulfonamide;

N-[3-[1-(6-(2-(1-Methyl-1H-imidazole-4-sulfonylamino)-ethyl)-4-hydroxy-2-ox o-6-propyl-5,6-dihydro-2H-pyran-3-yl)-propyl]-phenyl]-1-methyl-1H-imidazole -4-sulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-2-pyridinesulfonamide;

4-Cyano-N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl) -propyl]-phenyl]-2-pyridinesulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-2-quinolinesulfonamide;

2-Hydroxy-N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-y l)-propyl]-phenyl]-benzenesulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-2-pyrimidinesulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-2-quinazolinesulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-7H-purine-6-sulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-1H-imidazole-2-sulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-1H-benzimidazole-2-sulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-thiazole-4-sulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-2-pyridinesulfonamide;

4-Cyano-N-[3-[1-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran- 3-yl)-propyl]-phenyl]-2-pyridinesulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-2-quinolinesulfonamide;

2-Hydroxy-N-[3-[1-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyra n-3-yl)-propyl]-phenyl]-benzenesulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-2-pyrimidinesulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-2-quinazolinesulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-7H-purine-6-sulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-1H-imidazole-2-sulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-1H-benzimidazole-2-sulfonamide;

N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-thiazole-4-sulfonamide;

4-Fluoro-N-[3-[1-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran -3-yl)-propyl]-phenyl]-benzenesulfonamide;

5-cyano-N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl) -propyl]-phenyl]-N-methyl-2-pyridinesulfonamide;

N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-2-quinolinesulfonamide;

N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-2-imidazolesulfonamide;

N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-2-pyrimidinesulfonamide;

N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-2-benzimidazolesulfonamide;

N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-2-quinazolinesulfonamide;

N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -5 phenyl]-N-methyl-6-purinesulfonamide;

N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-4-thiazolesulfonamide;

N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-2-pyridinesulfonamide;

N-[3-(1-[5,6-Dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-propyl-2H-pyran-3-yl ]-2,2-dimethylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-(1(S)-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl)-6-propyl-2H-pyra n-3-yl]-2,2-dimethylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-(1(R)-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl)-6-propyl-2H-pyra n-3-yl]-2,2-dimethylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-(1(S)-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl)-6-propyl-2H-pyra n-3-yl]-2,2-dimethylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-(1(R)-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl)-6-propyl-2H-pyra n-3-yl]-2,2-dimethylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-2,2-dimeth ylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-2,2-dimeth ylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide;

5-Cyano-N-[3-(1-[5,6-dihydro-4-hydoxy-2-oxo-6-(2-phenethyl)-6-propyl-2H-pyr an-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide;

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-phenethyl-6-propyl-2H-pyran-3-yl)pro pyl}phenyl]-5-cyanopyridine-2-sulfonamide; and

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)propyl}phen yl]-5-cyanopyridine-2-sulfonamide.

8. The compound of claim 2 selected from the group consisting of:

3-[cyclopropyl[3-[(4-cyanophenylsulfonyl)methyl]phenyl]methyl]-4-hydroxy-6- [1-(phenylmethyl)propyl]-2H-pyran-2-one;

3-[cyclopropyl[3-[(2-pyridinylsulfonyl)methylphenylmethyl]-4-hydroxy-6-[1-( phenylmethyl)propyl]-2H-pyran-2-one;

3-[cyclopropyl[3-[(1-methyl-4-imidazolylsulfonyl)methyl]phenyl]methyl)-4-hy droxy-6-[1-(phenylmethyl)propyl]-2H-pyran-2-one;

3-[cyclopropyl[3-[(5-cyano-2-pyridinylsulfonyl)methyl]phenyl]methyl]-4-hydr oxy-6-[1-(phenylmethyl)propyl]-2H-pyran-2-one;

3-[cyclopropyl[3-[(2-benzimidazolylsulfonyl)methyl]phenyl]methyl]-4-hydroxy -6-[1-(phenylmethyl)propyl]-2H-pyran-2-one;

3-[cyclopropyl[3-[(2-quinolinylsulfonyl)methyl]phenyl]methyl]-4-hydroxy-6-[ 1-(phenylmethyl)propyl]-2H-pyran-2-one;

N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl}-phenyl)-4-fluoro-benzenesulfonamide;

4-Cyano-N-(3-{cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hy droxy-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-benzenesulfonamide;

N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl}-phenyl)-8-quinolinesulfonamide;

N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl]-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

(R or S)-N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydrox y-2-oxo-2H-pyran-3-yl]-methyl]-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

(R or S)-N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydrox y-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl]-phenyl)-2-pyridinesulfonamide;

N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl}-phenyl)-1H-benzoimidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl}-phenyl)-1H-imidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl}-phenyl)-2-quinolinesulfonamide;

N-(3-{(Cyclopropyl-[4-hydroxy-6-(3-{2-methoxy-ethoxy}-propyl)-2-oxo-2H-pyra n-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethyl-3-{2-methoxy-ethoxy}-propyl)-4-hydroxy-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

4-Cyano-N-(3-{cyclopropyl-[6-(1-ethyl-3-{2-methoxy-ethoxy}-propyl)-4-hydrox y-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-benzenesulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethyl-3-{1-methyl-1H-imidazole-4-sulfonylamino}-pro pyl)-4-hydroxy-2-oxo-2H-pyran-3-yl-methyl}-phenyl)-1-methyl-H-imidazole-4-s ulfonamide;

N-(3-{[6-(3-Bromo-1-ethyl-propyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-cyclopropy l-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(3-{[6-(3-Azido-1-ethyl-propyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-cyclopropy l-methyl)-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

2-[[8-[[3-[3-[Cyclopropyl[3-[[(1-methyl-1H-imidazol-4-yl)sulfonyl]aminolphe nyl]methyl]-4-hydroxy-2-oxo-2H-pyran-6-yl]pentyl]amino]-1,8-dioxooctyl]meth ylamino]-ethane sulfonic acid, monosodium salt;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-[(2-hydroxy-1,1-bisfhydroxymethyl}-ethyl) -amino]-carbonyl}-amino-propyl)-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-benzen esulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[(2-hydroxy-1,1-bis{hydroxymethyl}-ethyl )-amino]-carbonyl}-amino-propyl)-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-2-pyr idinesulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{(2-hydroxy-1,1-bisthydroxymethyl}-ethyl) -amino-carbonyl}-amino-propyl)-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1H-imid azole-2-sulfonamide;

N-(3-Cyclopropyl-[4-hydroxy-6-(3-{[(2-hydroxy-1,1-bis{hydroxymethyl}-ethyl) -amino]-carbonyl}-amino-propyl)-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1H-ben zoimidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[(2-hydroxy-1,1-bis{hydroxymethyl}-ethyl )-amino]-carbonyl}-amino-propyl)-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1-met hyl-1H-imidazole-4-sulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[(2-hydroxy-1,1-bis{hydroxymethyl}-ethyl )-amino]-carbonyl}-amino-propyl)-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1-met hyl-1H-imidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{.gamma.-L-glutamyl}-amino-propyl)-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-benzenesulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{.gamma.-L-glutamyl}-amino-propyl)-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-2-pyridinesulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{.gamma.-L-glutamyl}-amino-propyl)-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-1H-imidazole-sulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{.gamma.-L-glutamyl}-amino-propyl)-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-1H-benzoimidazole-sulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{.gamma.-L-glutamyl}-amino-propyl)-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{.gamma.-L-glutamyl}-amino-propyl)-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[piperazin-1-yl]-carbonyl}-amino-propyl) -2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-benzenesulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[piperazin-1-yl]-carbonyl}-amino-propyl) -2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-2-pyridinesulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[piperazin-1-yl]-carbonyl}-amino-propyl) -2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1H-imidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[piperazin-1-yl]-carbonyl}-amino-propyl) -2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1H-benzoimidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[piperazin-1-yl]-carbonyl}-amino-propyl) -2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[piperazin-1-yl]-carbonyl}-amino-propyl) -2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-2-sulfonamide;

2-[[8-[[3-[3-[Cyclopropyl[3-[[phenylsulfonyl]amino]phenyl]methyl]-4-hydroxy -2-oxo-2H-pyran-6-yl]propyl]amino]-1,8-dioxooctyl]methylamino]-ethanesulfon ic acid, monosodium salt;

2-[[8-[[3-[3-[Cyclopropyl[3-[[(2-pyridyl)sulfonyl]amino]phenyl]methyl]-4-hy droxy-2-oxo-2H-pyran-6-yl]propyl]amino]-1,8-dioxooctyl]methylamino]-ethane sulfonic acid, monosodium salt;

2-[[8-[[3-[3-[Cyclopropyl[3-[[(1H-benzimidazol-2-yl)sulfonyl]amino]phenyl]m ethyl]-4-hydroxy-2-oxo-2H-pyran-6-yl]propyl]amino]-1,8-dioxooctyl]methyl amino]-ethanesulfonic acid, monosodium salt;

2-[[8-[[3-[3-[Cyclopropyl[3-[[(1H-imidazol-2-yl)sulfonyl]amino]phenyl]methy l]-4-hydroxy-2-oxo-2H-pyran-6-yl]propyl]amino]-1,8-dioxooctyl]methylamino]- ethane sulfonic acid, monosodium salt;

2-[[8-[[3-[3-[Cyclopropyl[3-[[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino]phe nyl]methyl]-4-hydroxy-2-oxo-2H-pyran-6-yl]propyl]amino]-1,8-dioxooctyl]meth ylamino]-ethanesulfonic acid, monosodium salt;

2-[[8-[[3-[3-[Cyclopropyl[3-[[(1-methyl-1H-imidazol-2-yl)sulfonyl]amino]phe nyl]methyl]-4-hydroxy-2-oxo-2H-pyran-6-yl]propyl]amino]-1,8-dioxooctyl]meth ylamino]-ethane sulfonic acid, monosodium salt;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(3-(R or S)-{Cyclopropyl-[6-(1-(S)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(3-(R or S)-{Cyclopropyl-[6-(1-(S)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-2-pyridinesulfonamide;

N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-2-pyridinesulfonamide;

N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-1-methyl-1H-imidazole-2-sulfonamide;

N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-1-methyl-1H-imidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-2-sulfonamide;

N-(3-[Cyclopropyl[4-hydroxy-2-oxo-6-[1-[(tetrahydro-2H-pyran-3-yl)methyl]pr opyl]-2H-pyran-3-yl]methyl]phenyl]-8-quinolinesulfonamide;

N-(3-[Cyclopropyl[4-hydroxy-2-oxo-6-[1-[(tetrahydro-2H-pyran-3-yl)methyl]pr opyl]-2H-pyran-3-yl]methyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-(3-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]- methyl}-phenyl)-benzimidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]- methyl}-phenyl)-1H-imidazole-2-sulfonamide;

N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-4-cyanobenzenesulfonamide;

N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-4-cyanobenzenesulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-4-nitrobenzenesulfonamide;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-2-pyridinesulfonamide;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-4-cyano-2-pyridinesulfonamide;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-2-quinolinesulfonamide;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-2-hydroxybenzenesulfonamide;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-2-pyrazolesulfonamide;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-2-quinazolinesulfonamide;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-7H-purine-6-sulfonamide;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-1H-imidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-benzimidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-thiazole-4-sulfonamide;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-4-ethoxycarbonyl-1H-imidazole-2-sulfaonami de;

N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-3-hydroxy-2-pyridinesulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-2-pyridinesulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-4-cyano-2-pyridinesulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-2-quinolinesulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-2-hydroxybenzenesulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-ethy l}-phenyl)-2-pyrazolesulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-ethy l}-phenyl)-2-quinazolinesulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-ethy l}-phenyl)-7H-purine-6-sulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-1H-imidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-benzimidazole-2-sulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-thiazole-4-sulfonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-4-ethoxycarbonyl-1H-imidazole-2-sulfaonamide;

N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-3-hydroxy-2-pyridinesulfonamide;

5-cyano-N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-p yrone]-N-methyl-2-pyridinesulfonamide;

N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyronel-N -methyl-2-quinolinesulfonamide;

N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyrone]-N -methyl-2-imidazolesulfonamide;

N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyrone]-N -methyl-2-pyrimidinesulfonamide;

N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyrone]-N -methyl-2-benzimidazolesulfonamide;

N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyronel-N -methyl-2-quinazolinesulfonamide;

N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyrone]-N -methyl-6-purinesulfonamide;

N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyrone]-N -methyl-4-thiazolesulfonamide; and

N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyrone]-N -methyl-2-pyridinesulfonamide.

9. The compound of claim 1 of the formula VI ##STR145##

wherein R.sub.2 is

a) H.sub.3 C--CH.sub.2 --,

b) H.sub.3 C--(CH.sub.2).sub.2 --,

c) cyclopropyl-(CH.sub.2).sub.2 --,

d) F-phenyl-(CH.sub.2).sub.2 --,

e) het-SO.sub.2 NH-phenyl-,

f) (H.sub.3 C).sub.2 HC--CH.sub.2,

g) phenyl-(CH.sub.2).sub.2 --, or

h) F.sub.3 C--(CH.sub.2).sub.2 --;

wherein R.sub.3 is the moiety of formula X ##STR146##

wherein R.sub.6 is

a) H.sub.3 C--CH.sub.2 --,

b) H.sub.3 C--(CH.sub.2).sub.2 --,

c) cyclopropyl-(CH.sub.2).sub.2 --,

d) F-phenyl-(CH.sub.2).sub.2 --,

e) het-SO.sub.2 NH-phenyl,

f) (H.sub.3 C).sub.2 HC--CH.sub.2,

g) phenyl-(CH.sub.2).sub.2 --, or

h) F.sub.3 C--(CH.sub.2).sub.2 --;

wherein R.sub.7 is

a) H.sub.3 C--CH.sub.2 --,

b) t-butyl, or

c) cyclopropyl

wherein R.sub.9 is

a) --NHSO.sub.2 -het, or

b) --NHSO.sub.2 -phenyl substituted by one (1) R.sub.1 l;

wherein het is the following, substituted by zero (0) or one (1) R.sub.10,

a) imidazol-4-yl,

b) 2-pyridinyl, or

c) quinolin-8-yl;

wherein R.sub.10 is,

a) --CH.sub.3,

b) --CN,

c) --CF.sub.3,

d) --NH.sub.2, or

e) --C(O)--NH.sub.2 ;

wherein R.sub.11 is CN.

10. The compound of claim 9 selected from the group consisting of:

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-(4-fluorophenyl)ethyl)-2H-py ran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-(4-fluorophenyl)ethyl)-2H-py ran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide;

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-(4-fluorophenyl)ethyl)-2H-py ran-3-yl)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-(4-fluorophenyl)ethyl)-2H-py ran-3-yl)-2,2-dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide;

N-[3-(l-[6,6-Bis-(2-cyclopropyl-ethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran -3-yl]propyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-(1-[6,6-Bis-(2-cyclopropyl-ethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran -3-yl]propyl)phenyl]-5-cyano-2-pyridinesulfonamide;

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide;

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamid e;

N-(3-[1-(6-Ethyl-5,6-dihydro-4-hydroxy-6-[3-([(l-methyl-1H-imidazol-4-yl)su lfonyl]amino)phenyl]-2-2H-pyran-3-yl)propyl]phenyl)-1-methyl-1H-imidazole-4 -sulfonamide;

5-Cyano-N-(3-[1-(6-[3-([(5-cyano-2-pyridinyl)sulfonyl]amino)phenyl]-6-ethyl -5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3-yl)propyl]phenyl)-2-pyridinesulfona mide;

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide;

N-[3-(1-[6,6-Bis-(2-cyclopropyl-ethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran -3-yl]-2,2-dimethyl-propyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-(1-[6,6-Bis-(2-cyclopropyl-ethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran -3-yl]-2,2-dimethyl-propyl)phenyl]-5-cyano-2-pyridinesulfonamide,

5-cyano-N-[3-(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R or S)-(3,3,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyr idinesulfonamide,

5-cyano-N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide,

5-cyano-N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(S)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide,

5-cyano-N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(S)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide,

5-cyano-N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide,

N-[3-(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(R or S)-(2-phenethyl)-6-(3,3,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylprop yl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(R)-(2-phenethyl)-6-(3,3,3-trifl uoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole -4-sulfonamide,

N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(S)-(2-phenethyl)-6-(3,3,3-trifl uoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole -4-sulfonamide,

N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(S)-(2-phenethyl)-6-(3,3,3-trifl uoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole -4-sulfonamide,

N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(R)-(2-phenethyl)-6-(3,3,3-trifl uoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole -4-sulfonamide,

5-amino-N-[3-(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R or S)-(3,3,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyr idinesulfonamide,

5-amino-N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide,

5-amino-N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(S)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide,

5-amino-N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide,

5-amino-N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(S)-(3,3 ,3trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesulf onamide,

N-[3-(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-[6-(R or S)-propyl]-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesulfonamide ,

N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R)-propyl-2H-py ran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesulfonamide,

N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(S)-propyl-2H-py ran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesulfonamide,

N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R)-propyl-2H-py ran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesulfonamide,

N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(S)-propyl-2H-py ran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro-2H-p yran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro-2H-pyran-3-yl]-propyl]- phenyl]-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide,

4-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro-2H-pyran-3-yl]-propyl]- phenyl]-2-pyridinesulfonamide,

4-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide,

4-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro-2H-pyran-3-yl]-2,2-dime thylpropyl]-phenyl]-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]1-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]1-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-phenethyl-5,6-dihydro-2H-pyran-3-yl]-propyl] -phenyl]-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-phenethyl-5,6-dihydro -2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-phenethyl-5,6-dihydro -2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide,

4-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-phenethyl-5,6-dihydro-2H-pyran-3-yl]-propyl] -phenyl]-2-pyridinesulfonamide,

4-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-phenethyl-5,6-dihydro -2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide,

4-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-phenethyl-5,6-dihydro -2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide,

4-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro-2H-pyran-3-yl]-2,2-dime thylpropyl]-phenyl]-2-pyridinesulfonamide,

4-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfonamide,

4-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-n- propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenethyl)-6(R or S)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfonami de,

5-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide,

5-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide,

5-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide,

5-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide,

4-Trifluoromethyl-N-[3(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenethyl)-6(R or S)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfonami de,

4-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide,

4-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide,

4-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide,

4-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide,

5-Trifluoromethyl-N-[3(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenethyl)-6(R or S)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridine sulfonamide,

5-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide,

5-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide,

5-Amino-N-[3-(1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H- pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

5-Cyano-N-[3(R or S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-py ridine-sulfonamide,

5-Cyano-N-[3(R)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

5-Cyano-N-[3(R)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

5-Cyano-N-[3(S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

5-Cyano-N-[3(S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

5-Cyano-N-[3-(1-[5,6-dihydro-6,6-diisobutyl-4-hydroxy-2-oxo-2H-pyran-3-yl]p ropyl)phenyl]-2-pyridinesulfonamide,

N-[3-(1-[5,6-Dihydro-6,6-diisobutyl-4-hydroxy-2-oxo-2H-pyran-3-yl]-2,2-dime thylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

5-Cyano-N-[3-(1-[5,6-dihydro-6,6-diisobutyl-4-hydroxy-2-oxo-2H-pyran-3-yl]- 2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

N-[3(R or S)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(R or S)-[2-phenylethyl]-6-propyl-2H-pyran-3-yl)-2,2-dimethylpropyl]phenyl]-1-me thyl-1H-imidazole-4-sulfonamide,

N-[3(R)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(R)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3(R)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(S)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3(S)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(R)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3(S)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(S)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

5-Cyano-N-[3-(1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H- pyran-3-yl]cyclopropylmethyl)phenyl]-2-pyridinesulfonamide,

5-Amino-N-[3(R or S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-py ridine-sulfonamide,

5-Amino-N-[3(R)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

5-Amino-N-[3(S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

5-Amino-N-[3(S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

5-Amino-N-[3(R)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

5-Amino-N-[3(R or S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl)phenyl]-2-pyridinesulfona mide,

5-Amino-N-[3(R)-(-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenylethyl)-6-propy l-2H-pyran-3-yl]propyl)phenyl]-2-pyridinesulfonamide,

5-Amino-N-[3(R)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]propyl)phenyl]-2-pyridinesulfonamide,

5-Amino-N-[3(S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]propyl)phenyl]-2-pyridinesulfonamide,

5-Amino-N-[3(S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]propyl)phenyl]-2-pyridinesulfonamide,

5-Amino-N-[3(R or S)-(1-[6(R or S)-(2-[4-fluorophenyl]ethyl)-5,6-dihydro-4-hydroxy-2-oxo-6-propyl-2H-pyran -3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridine-sulfonamide,

5-Amino-N-[3(R)-(1-[6(R)-(2-[4-fluorophenyl]ethyl)-5,6-dihydro-4-hydroxy-2o xo-6-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide ,

5-Amino-N-[3(R)-(1-[6(S)-(2-[4-fluorophenyl]ethyl)-5,6-dihydro-4-hydroxy-2- oxo-6-propyl-2H-pyran-3-yl-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide ,

5-Amino-N-[3(S)-(1-[6(R)-(2-[4-fluorophenyl]ethyl)-5,6-dihydro-4-hydroxy-2- oxo-6-propyl-2H-pyran-3-yl-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide ,

5-Amino-N-[3(S)-(1-[6(S)-(2-[4-fluorophenyl]ethyl)-5,6-dihydro-4-hydroxy-2- oxo-6-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamid e,

N-[3(R or S)-(1-[5,6-Dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl]-2,2-dimethy lpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3(R)-(-[5,6-Dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl]-2,2-dime thylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3(S)-(-[5,6-Dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl]-2,2-dime thylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

5-Amino-N-[3(R or S)-(1-[5,6-dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl]-2,2-dimethy lpropyl)phenyl]-2-pyridinesulfonamide,

5-Amino-N-[3(R)-(1-[5,6-dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl] -2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

5-Amino-N-[3(S)-(1-[5,6-dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl] -2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

5-Cyano-N-[3(R or S)-(1-[5,6-dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl]-2,2-dimethy lpropyl)phenyl]-2-pyridinesulfonamide,

5-Cyano-N-[3(R)-(1-[5,6-dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl] -2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

5-Cyano-N-[3(S)-(1-[5,6-dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl] -2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide,

N-[3(R or S)-(1-[6,6-Bis(2-phenylethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3-yl]pr opyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3(R)-(1-[6,6-Bis(2-phenylethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3-y l]propyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3(S)-(1-[6,6-Bis(2-phenylethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3-y l]propyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3(R or S)-(1-[6,6-Bis(2-phenylethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3-yl]pr opyl)phenyl]-5-cyano-2-pyridinesulfonamide,

N-[3(R)-(1-[6,6-Bis(2-phenyl-ethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3- yl]propyl)phenyl]-5-cyano-2-pyridinesulfonamide,

N-[3(S)-(1-[6,6-Bis(2-phenyl-ethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3- yl]propyl)phenyl]-5-cyano-2-pyridinesulfonamide,

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-4-cyanobenzenesulfonamide,

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-8-quinolinesulfonamide,

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)p ropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)p ropyl}phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)propyl}phenyl]-5-carbamoylpyridine-2-sulfonamide,

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-(4-fluorophenyl)ethyl)-2H-py ran-3-yl)propyl}phenyl]-5-carbamoylpyridine-2-sulfonamide,

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)propyl}phen yl]-5-carbamoylpyridine-2-sulfonamide,

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-phenethyl-6-propyl-2H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfo namide,

N-[3-1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-phenethyl-6-propyl-2H-pyran-3-y l)propyl]phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-phenethyl-6-propyl-2H-pyran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4 -sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)- 2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)- 2,2-dimethylpropyl]phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-(2-(4-fluorophenyl)ethyl)-6-propyl-2H-pyran-3-yl)-2,2-dimethylpropyl}ph enyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl]phenyl]-5-cyanopyridine-2-sulfonamid e,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl]phenyl]-5-cyanopyridine-2-sulfonamid e,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl,phenyl]-5-cyanopyridine-2-sulfonamid e,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamid e,

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-(2-(4-fluorophenyl)ethyl)-6-propyl-2H-pyran-3-yl)-2,2-dimethylpropyl}ph enyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulf onamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulf onamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulf onamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulf onamide,

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)-2,2- dimethylpropyl}phenyl]-5-aminopyridine-2-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-y l)-2,2-dimethylpropyl}phenyl]-5-aminopyridine-2-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-y l)-2,2-dimethylpropyl}phenyl]-5-aminopyridine-2-sulfonamide,

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)-2,2- dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-y l)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-y l)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)-2,2- dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-y l)-2,2-dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-y l)-2,2-dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl}phenyl} -5-cyanopyridine-2-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl} phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl} phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl}phenyl] -5-aminopyridine-2-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl} phenyl]-5-aminopyridine-2-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl} phenyl]-5-aminopyridine-2-sulfonamide,

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-(2-(4-fluorophenyl)ethyl)-6-propyl-2H-pyran-3-yl)propyl}phenyl]-5-cyano pyridine-2-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide,

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-(2-(4-fluorophenyl)ethyl)-6-propyl-2H-pyran-3-yl)propyl}phenyl]-1-methy l-1H-imidazole-4-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide,

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-(2-(4-fluorophenyl)ethyl)-6-propyl-2H-pyran-3-yl)propyl}phenyl]-5-amino pyridine-2-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-aminopyridine-2-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-aminopyridine-2-sulfonamide,

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-aminopyridine-2-sulfonamide,

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-5 propyl-2H-pyran-3-yl)propyl}phenyl]-5-aminopyridine-2-sulfonamide,

N-[3-[1-(S)-[5,6,-Dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyr an-3-yl]propyl]phenyl]-5-(triflouromethyl)-2-pyridinesulfonamide

(3S,6R)-N-[3-[1-[5,6,-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H -pyran-3-yl]propyl]phenyl]-5-(triflouromethyl)-2-pyridinesulfonamide

(3S)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6,6-dipropyl-2H-pyran-3-yl)propyl ]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide

(3R)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6,6-dipropyl-2H-pyran-3-yl)propyl ]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide (3R)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6-propyl-6-phenethyl-2H-pyran-3- yl)propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide

(3R,6S)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6-propyl-6-phenethyl-2H-pyran- 3-yl)propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide

(3S,6S)-N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H- pyran-3-yl]propyl]phenyl]-5-(triflouromethyl)-2-pyridinesulfonamide.

11. The compound of claim 9

wherein R.sub.2 is

a) H.sub.3 C--(CH.sub.2).sub.2 --, or

b) phenyl-(CH.sub.2).sub.2 --;

wherein R.sub.3 is the moiety of formula X;

wherein R.sub.6 is

a) H.sub.3 C--(CH.sub.2).sub.2 --, or

b) phenyl-(CH.sub.2).sub.2 --;

wherein R.sub.7 is

a) H.sub.3 C--CH.sub.2 --, or

b) t-butyl;

wherein R.sub.9 is --NHSO.sub.2 -het;

wherein het is the following, substituted by one (1) R.sub.10,

a) imidazol-4-yl, or

b) 2-pyridinyl;

wherein R.sub.10 is,

a) --CH.sub.3,

b) --CN, or

c) --CF.sub.3.

12. The compound of claim 11 selected from the group consisting of:

5-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro-2H-pyran-3-yl]-propyl]- phenyl]-2-pyridinesulfonamide;

5-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide; or (3R)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6,6-dipropyl-2H-pyran-3-yl)propy l]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide

5-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide; or (3S)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6,6-dipropyl-2H-pyran-3-yl)propy l]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide

5-Trifluoromethyl-N-[3(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenethyl)-6(R or S)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridine sulfonamide;

5-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide;

5-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide; or (3R,6S)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6-propyl-6-phenethyl-2H-pyran -3-yl)propy]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide

5-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide; or (3S,6R)-N-[3-[1-[5,6,-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2 H-pyran-3-yl]propyl]phenyl]-5-(triflouromethyl)-2-pyridinesulfonamide

5-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide; or (3S,6S)-N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H -pyran-3-yl]propyl]phenyl]-5-(triflouromethyl)-2-pyridinesulfonamide

N-[3-[1-(S)-[5,6,-Dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyr an-3-yl]propyl]phenyl]-5-(triflouromethyl)-2-pyridinesulfonamide

(3R)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6-propyl-6-phenethyl-2H-pyran-3-y l)propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide

N-[3(R or S)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(R or S)-[2-phenylethyl]-6-propyl-2H-pyran-3-yl)-2,2-dimethylpropyl]phenyl)-1-me thyl-1H-imidazole-4-sulfonamide;

N-[3(R)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(R)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3(R)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(S)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3(S)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(R)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3(S)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(S)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide;

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl}phenyl] -5-cyanopyridine-2-sulfonamide;

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl} phenyl]-5-cyanopyridine-2-sulfonamide;

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl} phenyl]-5-cyanopyridine-2-sulfonamide;

N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-phenethyl-6-propyl-2H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfo namide;

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide;

N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide;

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide; and

N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide.
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