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Claims for Patent: 6,156,331

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Claims for Patent: 6,156,331

Title: Sustained delivery of an active agent using an implantable system
Abstract:The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
Inventor(s): Peery; John R. (Stanford, CA), Dionne; Keith E. (Menlo Park, CA), Eckenhoff, deceased; James B. (late of Los Altos, CA), Landrau; Felix A. (Punta Gorda, FL), Lautenbach; Scott D. (San Mateo, CA), Magruder; Judy A (Mountain View, CA), Wright; Jeremy C. (Los Altos, CA)
Assignee: ALZA Corporation (Mountain View, CA)
Application Number:09/310,149
Patent Claims: 1. A fluid-imbibing device for delivering an active agent to a fluid environment of use, said device comprising a water-swellable semipermeable material in the form of a plug that is received in sealing relationship with the interior surface of one end of an impermeable reservoir and an active agent to be displaced from the device when the water swellable material swells, wherein the semipermeable material is assembled into an open end of the reservoir.

2. The device of claim 1 wherein the semipermeable material is selected from the group consisting of plasticized cellulosic materials, polyurethanes and polyamides.

3. The device of claim 1 wherein the aspect ratio of the plug is 1:10 to 10:1 length to diameter.

4. A fluid-imbibing device for delivering an active agent to a fluid environment of use, said device comprising a water-swellable semipermeable material in the form of a plug that is received in sealing relationship with the interior surface of one end of an impermeable reservoir and an active agent to be displaced from the device when the water swellable material swells, wherein the semipermeable material is assembled into a cavity in said reservoir.

5. The device of claim 4 wherein the cavity is of a shape selected from the group consisting of a cylindrical, stepped, helical threaded and spaced configuration.

6. The device of claim 1 wherein the active agent is selected from the group consisting of a protein, a peptide or a gene therapy agent.

7. The device of claim 6 wherein the active agent is an LHRH agonist or antagonist.

8. The device of claim 6 wherein the active agent is leuprolide.

9. The device of claim 6 wherein the active agent is selected from the group consisting of Factor VIII and Factor IX.

10. The device of claim 1 wherein the active agent is delivered to a site remote from the device.

11. A semipermeable plug useful in an active agent delivery system for delivering active agent to a fluid environment of use, wherein said system comprises an impermeable reservoir, said plug being water-swellable and expanding linearly in said delivery system to commence pumping of active agent upon insertion of the delivery system in the fluid environment of use, wherein the semipermeable plug is assembled into an open end of said reservoir.
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