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Claims for Patent: 6,147,095

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Claims for Patent: 6,147,095

Title: Method for improving the pharmacokinetics of tipranavir
Abstract:The present invention relates to a novel method for improving the pharmacokinetics of tipranavir, comprising administering to a human in need of such treatment a combination of a therapeutically effective amount of tipranavir or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of ritonavir or a pharmaceutically acceptable salt thereof.
Inventor(s): Ferry; James J. (Kalamazoo, MI), Baldwin; John R. (Portage, MI), Borin; Marie T. (Kalamazoo, MI)
Assignee: Pharmacia & Upjohn Company (Kalamazoo, MI)
Application Number:09/430,742
Patent Claims: 1. A method for improving the pharmacokinetics of tipranavir, comprising administering to a human in need of such treatment a combination of a therapeutically effective amount of tipranavir or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of ritonavir or a pharmaceutically acceptable salt thereof.

2. The method of claim 1, wherein said therapeutically effective amount of tipranavir is between about 200 mg and about 6750 mg of tipranavir, and said therapeutically effective amount of ritonavir is between about 30 mg and about 1000 mg of ritonavir.

3. The method of claim 1, wherein said therapeutically effective amount of tipranavir is between about 200 and about 900 mg of tipranavir, and said therapeutically effective amount of ritonavir is between about 30 and about 500 mg of ritonavir.

4. The method of claim 1, wherein said therapeutically effective amount of tipranavir is between about 200 and about 900 mg of tipranavir, and said therapeutically effective amount of ritonavir is between about 30 and about 300 mg of ritonavir.

5. The method of claim 1, wherein said therapeutically effective amount of tipranavir is between about 200 and about 600 mg of tipranavir, and said therapeutically effective amount of ritonavir is between about 30 and about 500 mg of ritonavir.

6. The method of claim 1, wherein said therapeutically effective amount of tipranavir is between about 200 and about 600 mg of tipranavir, and said therapeutically effective amount of ritonavir is between about 30 and about 300 mg of ritonavir.

7. The method of claim 1, wherein said therapeutically effective amount of tipranavir is between about 200 and about 600 mg of tipranavir, and said therapeutically effective amount of ritonavir is between about 30 and about 100 mg of ritonavir.

8. A method for increasing human blood levels of tipranavir, comprising administering to a human in need of such treatment a combination of a therapeutically effective amount of tipranavir or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of ritonavir or a pharmaceutically acceptable salt thereof.

9. The method of claim 8, wherein said therapeutically effective amount of tipranavir is between about 200 mg and about 6750 mg of tipranavir, and said therapeutically effective amount of ritonavir is between about 30 mg and about 1000 mg of ritonavir.

10. The method of claim 8, wherein said therapeutically effective amount of tipranavir is between about 200 and about 900 mg of tipranavir, and said therapeutically effective amount of ritonavir is between about 30 and about 500 mg of ritonavir.

11. The method of claim 8, wherein said therapeutically effective amount of tipranavir is between about 200 and about 900 mg of tipranavir, and said therapeutically effective amount of ritonavir is between about 30 and about 300 mg of ritonavir.

12. The method of claim 8, wherein said therapeutically effective amount of tipranavir is between about 200 and about 600 mg of tipranavir, and said therapeutically effective amount of ritonavir is between about 30 and about 500 mg of ritonavir.

13. The method of claim 8, wherein said therapeutically effective amount of tipranavir is between about 200 and about 600 mg of tipranavir, and said therapeutically effective amount of ritonavir is between about 30 and about 300 mg of ritonavir.

14. The method of claim 8, wherein said therapeutically effective amount of tipranavir is between about 200 and about 600 mg of tipranavir, and said therapeutically effective amount of ritonavir is between about 30 and about 100 mg of ritonavir.
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