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|Title:||Oral pharmaceutical preparation containing ibandronat|
|Abstract:||The invention is directed to well-tolerated pharmaceutical compositions for oral application, containing ibandronate or a physiologically tolerable salt thereof as active substance, the administration form consisting of an active substance-containing inner portion enclosed in such fashion by a coat free of active substance that rapid release of the active substance takes place.|
|Inventor(s):||Mockel; Jorn (Heidelberg, DE), Gabel; Rolf-Dieter (Schwetzingen, DE), Woog; Heinrich (Laudenbach, DE)|
|Assignee:||Roche Diagnostics GmbH (Mannheim, DE)|
1. A method of treating a bone disease in a patient in need thereof, comprising orally administering to the patient a pharmaceutical formulation comprising a tablet core
containing about 0.1 to 100 mg of ibandronate and a coating which is free of ibandronate and has the following proportional composition:
(a) about 51.425% by weight of methylhydroxypropylcellulose;
(b) about 24.650% by weight of titanium dioxide;
(c) about 15.000% by weight of polyethylene glycol; and
(d) about 8.925% by weight of talc.
2. The method of claim 1, wherein the bone disease is related to a disorder in calcium metabolism.
3. The method of claim 1, wherein the bone disease is selected from the group consisting of hypercalcemia, osteoporosis, tumor osteolysis, and Paget's disease.
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