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Claims for Patent: 6,133,418

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Claims for Patent: 6,133,418

Title: Synthetic peptide inhibitors of HIV transmission
Abstract:The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP-178 (SEQ ID:1) ptide corresponding to amino acids 638 to 673 of the HIV-1.sub.LAI gp41 protein, and fragments, analogs and homologs of DP-178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
Inventor(s): Bolognesi; Dani Paul (Durham, NC), Matthews; Thomas James (Durham, NC), Wild; Carl T. (Durham, NC)
Assignee: Duke University (Durham, NC)
Application Number:08/554,616
Patent Claims: 1. A peptide having the formula

in which amino acid residues are presented by the single-letter code wherein:

X is an amino group, an acetyl group, a 9-fluorenylmethoxy-carbonyl group, or a hydrophobic group; and

Z is a carboxyl group, an amido group, or a hydrophobic group.

2. A peptide having the formula

in which amino acid residues are presented by the single-letter code wherein:

X is an acetyl group; and

Z is an amido group.

3. A pharmaceutical composition comprising an effective amount of the peptide of claim 2 and a pharmaceutically acceptable carrier or excipient.
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