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Claims for Patent: 6,133,289

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Claims for Patent: 6,133,289

Title: Paroxetine hydrochloride form A or C
Abstract:Invented are methods of treatment using novel forms of paroxetine hydrochloride anhydrate.
Inventor(s): Ward; Neal (Crowborough, GB), Jacewicz; Victor Witold (Turnbridge Wells, GB)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Application Number:08/922,067
Patent Claims: 1. A method for treating or preventing a disorder selected form: alcoholism, anxiety, depression, obsessive compulsive disorder, panic disorder, chronic pain, obesity, senile dementia, migraine, bulimia, anorexia, social phobia, pre-menstrual syndrome, adolescent depression tichotillomania, dysthymia and substance abuse which comprises administering an effective therapeutic or prophylactic amount of paroxetine hydrochloride anhydrate Form A to a patient in need thereof, wherein paroxetine hydrochloride anhydrate Form A comprises the following characteristics: a melting point of about 123-125.degree. C.; IR bands at about 513, 538, 571, 592, 613, 665, 722, 761, 783, 806, 818, 839, 888, 906, 924, 947, 966, 982, 1006, 1034, 1068, 1091, 1134, 119,4, 1221, 1248, 1286, 1340, 1387, 1493, 1513, 1562, 1604, 3402, and 3631 cm.sup.-1 ; a DSC maximum endoderm, measured at 10.degree. C. per minute, of about 126.degree. C. in an open pan and about 121.degree. C. in a closed pan; characteristic X-ray diffractogram peaks at about 6.6, 8.0, 11.2, and 13.1 degrees 2 theta; characteristic solid state .sup.13 C-NMR spectrum peaks at about 154.3, 149.3, 141.6, and 138.5 ppm.

2. A method according to claim 1 wherein the disorder is selected form: depression, obsessive compulsive disorder, panic disorder and social phobia.

3. A method according to claim 1 wherein the disorder is depression.

4. A method for treating or preventing a disorder selected form: alcoholism, anxiety, depression, obsessive compulsive disorder, panic disorder, chronic pain, obesity, senile dementia, migraine, bulimia, anorexia, social phobia, pre-menstrual syndrome, adolescent depression, trichotillomania, dysthymia and substance abuse which comprises administering an effective therapeutic or prophylactic amount of paroxetine hydrochloride anhydrate Form C to a patient in need thereof, wherein paroxetine hydrochloride anhydrate Form C comprises the following characteristics: a melting point of about 164.degree. C.; IR bands at about 540, 574, 615, 674, 720, 760, 779, 802, 829, 840, 886, 935, 965, 984, 1007, 1034, 1092, 1109, 1139, 1183, 1218, 1240, 1263, 1280, 1507, 1540, 1558, 1598, and 1652cm.sup.-1 ; a DSC maximum endotherm, measured at 10.degree. C. per minute, of about 161.degree. C. in both open and closed pans; characteristic X-ray diffractogram peaks at about 10.1, 12.1, 13.1, and 14.3 degrees 2 theta; characteristic solid state .sup.13 C-NMR spectrum peaks at about 154.0, 148.5, 143.4, and 140.4 ppm.

5. A method according to claim 4 wherein the disorder is selected form: depression, obsessive compulsive disorder, panic disorder and social phobia.

6. A method according to claim 4 wherein the disorder is depression.
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