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|Title:||Use of 7-(2-oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-quinolone carboxylic acid and naphthyridon carboxylic acid derivatives for the treatment of Helicobacter pylori infections and associated gastroduodenal diseases|
|Abstract:||The invention relates to the use of quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a 2-oxa-5,8-diazabicyclo[4.3.0]-non-8-yl) radical, and their pharmaceutically utilizable hydrates and/or salts for the therapy of Helicobacter pylori infections and the gastroduodenal disorders associated therewith.|
|Inventor(s):||Matzke; Michael (Wuppertal, DE), Petersen; Uwe (Leverkusen, DE), Jaetsch; Thomas (Koln, DE), Bartel; Stephan (Kurten, DE), Schenke; Thomas (Bergisch Gladbach, DE), Himmler; Thomas (Odenthal-Globusch, DE), Baasner; Bernd (Bergisch Gladbach, DE), Werling; Hans-Otto (Wuppertal, DE), Schaller; Klaus (Wuppertal, DE), Labischinski; Harald (Wuppertal, DE)|
|Assignee:||Bayer Aktiengesellschaft (Leverkusen, DE)|
1. A compound which is 8-cyano-1-cyclopropyl-6-fluoro-7-((1S,6S)-2-oxa-5,8-diazabicyclo [4.3.0]-non-8-yl)-1,4-dihydro-4-oxo-3-quinoline carboxylic acid of the formula:
##STR43## or a pharmaceutically utilizable hydrate and/or salt thereof.
2. A pharmaceutical composition comprising the compound according to claim 1 and a pharmaceutically utilizable carrier.
3. A method for treating a Helicobacter pylori infection and/or a gastroduodenal disorder associated with a Helicobacter pylori infection, said method comprising administering to a patient an effective amount therefor of the compound according to claim 1.
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