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Serving leading biopharmaceutical companies globally:

Deloitte
Harvard Business School
Mallinckrodt
Cipla
US Army
Cantor Fitzgerald
Colorcon
Healthtrust
McKinsey
Fish and Richardson

Generated: November 23, 2017

DrugPatentWatch Database Preview

Claims for Patent: 6,132,758

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Claims for Patent: 6,132,758

Title: Stabilized antihistamine syrup
Abstract:An antihistaminic syrup is stabilized against degradation of the active ingredient, by the addition of and about 0.05 to about 5 mg/mL of an aminopolycarboxylic acid such as a salt of ethylenediaminetetraacetic acid.
Inventor(s): Munayyer; Farah J. (West Caldwell, NJ), Guazzo; Frank (Bridgewater, NJ), Stupak; Elliot I. (West Caldwell, NJ), Chaudry; Imtiaz A. (North Caldwell, NJ), Sequeira; Joel A. (Edison, NJ)
Assignee: Schering Corporation (Kenilworth, NJ)
Application Number:09/088,128
Patent Claims: 1. An antihistaminic syrup comprising loratadine and about 0.05 to about 5 mg/mL of an aminopolycarboxylic acid or a salt thereof.

2. The syrup of claim 1, wherein the aminopolycarboxylic acid is selected from the group consisting of: iminodiacetic acid; methyliminodiacetic acid; nitrilotriacetic acid; ethylenediaminetetraacetic acid; diethylenetriaminepentaacetic acid; 1,2-diaminocyclohexane-tetraacetic acid; N-hydroxyethylenediaminetriacetic acid; and any combination of two or more thereof.

3. The syrup of claim 1, wherein the aminopolycarboxylic acid comprises ethylenediaminetetraacetic acid.

4. The syrup of claim 1, in which the aminopolycarboxylic acid comprises about 0.1 to 1 mg/mL of said syrup.

5. The syrup of claim 4, in which the aminopolycarboxylic acid comprises about 0.25 to about 0.5 mg/mL of said syrup.

6. The syrup of claim 1, further containing a therapeutically effective amount of a decongestant, an analgesic, an antitussive, an expectorant, or any combination of two or more thereof.

7. The syrup of claim 1, further comprising a decongestant selected from the group consisting of pseudoephedrine and phenylpropanolamine.

8. The syrup of claim 1, further comprising pseudoephedrine.

9. The syrup of claim 1, further comprising an analgesic.

10. The syrup of claim 8, further comprising an analgesic.

11. A storage-stable loratadine syrup comprising less than 0.49% by weight of 2-hydroxymethyl loratadine.

12. A storage-stable loratadine syrup comprising less than 0.53% by weight of 4-hydroxymethyl loratadine.

13. An antihistaminic syrup comprising loratadine and an aminopolycarboxylic acid.

14. The antihistaminic syrup of claim 13, wherein the aminopolycarboxylic acid is present in an amount sufficient to inhibit degradation of said loratadine.

15. The antihistaminic syrup of claim 13, wherein the aminopolycarboxylic acid comprises ethylenediaminetetraacetic acid.

16. The antihistaminic syrup of claim 15, wherein the ethylenediaminetetraacetic acid is present in an amount sufficient to inhibit degradation of said loratadine.
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Serving leading biopharmaceutical companies globally:

Chinese Patent Office
Moodys
Healthtrust
Fuji
Cerilliant
Daiichi Sankyo
Farmers Insurance
Johnson and Johnson
US Army
Citi

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