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Summary for Patent: 6,130,208
|Title:||Formulation containing a nucleotide analogue|
|Abstract:||A pharmaceutical composition comprising a nucleotide analogue and one or more glass forming additives which is suitable for freeze drying.|
|Inventor(s):||Broadhead; Joanne (Loughborough, GB)|
|Assignee:||AstraZeneca UK Limited (London, GB)|
1. A pharmaceutical composition comprising a nucleotide analog and one or more glass forming additives, wherein the nucleotide is a compound of formula (I): ##STR6## wherein
R.sup.1 and R.sup.2 independently represent hydrogen or halogen, R.sup.3 and R.sup.4 independently represent phenyl, or C.sub.1-6 -alkyl optionally substituted by one or more substituents selected from OR.sup.5, C.sub.1-6 -alkylthio, NR.sup.6 R.sup.7,
phenyl, COOR.sup.8 and halogen,
R.sup.5, R.sup.6, R.sup.7 and R.sup.8 independent represent hydrogen or C.sub.1-6 -alkyl and X represents an acidic moiety, or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition according to claim 1 which is in freeze-dried, spray dried or vacuum dried form.
3. A pharmaceutical composition according to claim 1 which is in reconstituted form.
4. A pharmaceutical composition according to claim 1 and further including a modifying agent.
5. A pharmaceutical composition according to claim 4, in which the modifying agent is sucrose.
6. A method of treating a platelet aggregation disorder which method comprises treating a subject suffering from a said disorder with a therapeutically effective amount of a pharmaceutical composition as defined in claim 1.
7. A process for the preparation of a pharmaceutical composition according to claim 2 which process comprises mixing the ingredients of the composition, and either freezing them and drying the frozen mixture, or spray-drying them.
8. A method of treating acute coronary syndromes and percutaneous transluminal coronary angioplasty in a patient in need of said treatment, said method comprising the step of administering to said patient a therapeutically effective amount of a pharmaceutical composition as defined in claim 1.
9. A method of treating angina in a patient in need of said treatment, said method comprising the step of administering to said patient a therapeutically effective amount of a pharmaceutical composition as defined in claim 1.
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