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Claims for Patent: 6,087,367

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Claims for Patent: 6,087,367

Title: Potent inducers of terminal differentiation and methods of use thereof
Abstract:The present invention provides the compound having the structure: ##STR1## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 --N--R.sub.4, wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group and R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8. The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.
Inventor(s): Breslow; Ronald (Englewood, NJ), Marks; Paul A. (Bridgewater, CT), Rifkind; Richard A. (New York, NY), Jursic; Branko (New Orleans, LA)
Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY) The Trustees of Columbia University in the City of New York (New York, NY)
Application Number:09/314,195
Patent Claims: 1. A method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable conditions with an effective amount of the compound having the structure: ##STR108## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiazoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 -N-R.sub.4, wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group and R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, or alkyloxy group; and n is an integer from 4 to 8, or a pharmaceutically acceptable salt thereof; and wherein the amount of the compound is effective to selectively induce terminal differentiation.

2. A method of claim 1 wherein the R.sub.1 represents NHOH, R.sub.2 represents OH, and n represents 6.

3. A method of claim 1 wherein the compound has the structure: ##STR109## wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group; R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, or alkyloxy group; and n is an integer from 4 to 8, or a pharmaceutically acceptable salt thereof; and wherein the amount of compound is effective to selectively induce terminal differentiation.

4. A method of treating a patient having a tumor characterized by proliferation of neoplastic cells which comprises administering to the patient an effective amount of the compound having the structure: ##STR110## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiazoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 --N--R.sub.4, wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group and R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, or alkyloxy group; and n is an integer from 4 to 8, or a pharmaceutically acceptable salt thereof; and wherein the amount of compound is effective to selectively induce terminal differentiation of such neoplastic cells and thereby inhibit their proliferation.

5. A method of claim 4 wherein the R.sub.1 represents NHOH, R.sub.2 represents OH, and n represents 6.

6. A method of claim 4 wherein the compound has the structure: ##STR111## wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group; R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, or alkyloxy group; and n is an integer from 4 to 8, or a pharmaceutically acceptable salt thereof; and wherein the amount of compound is effective to selectively induce terminal differentiation of such neoplastic cells and thereby inhibit their proliferation.

7. A method of claim 4 wherein the R.sub.2 of the structure is a hydroxylamino, hydroxyl, amino, methylamino, or methyoxy group and n is 6.

8. A method of claim 4 wherein R.sub.4 of the structure is a hydrogen atom and R.sub.3 is a substituted or unsubstituted phenyl group.

9. A method of claim 8 wherein the phenyl group is substituted with a methyl, cyano, nitro, trifluoromethyl, amino, aminocarbonyl, methylcyano, chloro, fluoro, bromo, iodo, 2,3-difluoro, 2,4-difluoro, 2,5-difluoro, 3,4-difluoro, 3,5-difluoro, 2,6-difluoro, 1,2,3-trifluoro, 2,3,6-trifluoro, 2,4,6-trifluoro, 3,4,5-trifluoro, 2,3,5,6-tetrafluoro, 2,3,4,5,6-pentafluoro, azido, hexyl, t-butyl, phenyl, carboxyl, hydroxyl, methoxy, phenyloxy, benzyloxy, phenylaminooxy, phenylaminocarbonyl, methyoxycarbonyl, methylaminocarbonyl, dimethylamino, dimethylaminocarbonyl, or hydroxylaminocarbonyl group.

10. A method of claim 6, wherein R.sub.4 of the structure is a hydrogen atom and R.sub.3 is a cyclohexyl group.

11. A method of claim 6, wherein R.sub.4 of the structure is a hydrogen atom and R.sub.3 is a methyoxy group.

12. A method of claim 6, wherein R.sub.3 and R.sub. bond together to form a piperidine group.

13. A method of claim 6, wherein R.sub.4 of the structure is a hydrogen atom and R.sub.3 is a hydroxyl group.

14. A method of claim 6, wherein R.sub.4 of the structure is a hydrogen atom and R.sub.3 is a benzyloxy group.

15. A method of claim 6, wherein R.sub.4 of the structure is a hydrogen atom and R.sub.3 is a .delta.-pyridine group.

16. A method of claim 6, wherein R.sub.4 of the structure is a hydrogen atom and R.sub.3 is a .beta.-pyridine group.

17. A method of claim 6, wherein R.sub.4 of the structure is a hydrogen atom and R.sub.3 is a .alpha.-pyridine group.

18. A method of claim 6, wherein R.sub.3 and R.sub.4 are both methyl groups.

19. A method of claim 6, wherein R.sub.4 of the structure is a methyl group and R.sub.3 is a phenyl group.
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