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Claims for Patent: 6,071,537

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Claims for Patent: 6,071,537

Title: Anticonvulsant derivatives useful in treating obesity
Abstract:A method for treating obesity comprising administering a therapeutically effective amount of a compound of the formula: ##STR1## is disclosed.
Inventor(s): Shank; Richard P. (Blue Bell, PA)
Assignee: Ortho Pharmaceutical Corporation (Raritan, NJ)
Application Number:08/881,009
Patent Claims: 1. A method for treating obesity in a mammal comprising

administering to said mammal a therapeutically effective amount for treating such condition of a compound of the formula I: ##STR7## wherein X is CH.sub.2 or oxygen;

R.sub.1 is hydrogen or alkyl; and

R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently hydrogen or lower alkyl and, when X is oxygen, R.sub.2 and R.sub.3 and/or R.sub.4 and R.sub.5 together may be a methylenedioxy group of the following formula (II): ##STR8## wherein R.sub.6 and R.sub.7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.

2. The method of claim 1 wherein the compound of formula I is topiramate.

3. The method of claim 1, wherein the therapeutically effective amount is of from about 50 to 400 mg.

4. The method of claim 1, wherein the amount is of from about 25 to 200 mg.
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