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Claims for Patent: 6,063,771

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Claims for Patent: 6,063,771

Title: Formulations for controlling human lice
Abstract:Safer pediculicidal formulations comprising a spinosyn, or a physiologically acceptable derivative or salt thereof, and a physiologically acceptable carrier, and methods of controlling lice infestations in a human with these formulations are provided.
Inventor(s): Snyder; Daniel Earl (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:09/338,116
Patent Claims: 1. A pediculicidal shampoo comprising:

(a) from about 0.1% to about 30% of a spinosyn, or a physiologically acceptable tetracyclic N-demethyl derivative or salt thereof;

(b) from about 5% to about 30% of a synthetic surfactant;

(c) from about 1% to about 7% of an amide; and

(d) water.

2. A shampoo of claim 1 wherein the synthetic surfactant is anionic, amphoteric, cationic, zwitterionic, or non-ionic, or a mixture thereof.

3. A shampoo of claim 2 wherein the amide is coconut monoethanolamide or coconut diethanolamide or a mixture thereof.

4. A shampoo of claim 2 additionally comprising from about 1% to about 10% of a non-volatile silicone material.

5. A shampoo of claim 4 wherein the non-volatile silicone is a polyalkyl siloxane, polyalkylaryl siloxane or polyether siloxane co-polymer, or a mixture thereof, whose viscosity is from about 100 centipoise to about 150,000,000 centipoise at 25.degree..

6. A shampoo of claim 5 additionally comprising from about 0.5% to about 5% of a suspending agent selected from the group consisting of crystalline amphiphilic materials having needle-like or platelet structures, polymeric materials, clays and fumed metal oxides, or a mixture thereof.

7. A shampoo of claim 6 wherein the suspending agent is a crystalline amphiphilic material selected from the group consisting of long chain C.sub.16 -C.sub.22 acyl derivatives and long chain C.sub.16 -C.sub.22 alkanolamides of fatty acids, or a mixture thereof.

8. A shampoo of claim 7 wherein the suspending agent is an ethylene glycol diester.

9. A shampoo of claim 2 wherein the amount of a spinosyn, or tetracyclic N-demethyl derivative or salt thereof, is at a level from about 0.25% to about 1.5%.

10. A method for controlling a lice infestation in a human comprising topically administering to the human an effective amount of a formulation of spinosyn, or a physiologically acceptable tetracyclic N-demethyl derivative or salt thereof.

11. The method of claim 10 wherein the lice infestation is Pediculus humanus capitis.

12. The method of claim 10 wherein the lice infestation is Pediculus humanus humanus.

13. The method of claim 10 wherein the lice infestation is Pthirus pubis.

14. A method for treating human hair to kill and facilitate removal of lice and their eggs comprising the steps of:

(a) applying from about 10 g to about 30 g of a formulation comprising a spinosyn, or a physiologically acceptable tetracyclic N-demethyl derivative or salt thereof, and a physiologically acceptable carrier to wet hair;

(b) working the formulation through the hair and scalp;

(c) leaving the formulation on the hair and scalp for about 6-10 minutes;

(d) removing the formulation from the hair by rinsing, with water.
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