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Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Accenture
Cipla
UBS
Argus Health
Julphar
Citi
QuintilesIMS
Farmers Insurance
Merck

Generated: December 10, 2017

DrugPatentWatch Database Preview

Claims for Patent: 6,057,305

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Claims for Patent: 6,057,305

Title: Antiretroviral enantiomeric nucleotide analogs
Abstract:Resolved enantiomers of the formula ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.
Inventor(s): Holy ; Antonin (Praha, CS), Dvorakova ; Hana (Praha, CS), DeClercq; Erik Desire Alice (Lovenjoel, BE), Balzarini; Jan Marie Rene (Heverlee, BE)
Assignee: Institute of Organic Chemistry and Biochemistry of the Academy of (CZ) Rega Stichting, v.z.w. (BE)
Application Number:07/925,610
Patent Claims: 1. A method of achieving a human immunodeficiency virus or hepatitus B virus antiviral effect in a mammal in need of such treatment which comprises administering to said mammal an antivirally effective amount of a compound of the formula ##STR13## including physiologically acceptable salts of such compound, wherein said compound of Formula IA is the R isomer substantially free of its enantiomer and wherein B is a purine moiety substituted at the 6 position by amino, alkylamino, dialkylamino, or aralkylamino, and wherein R is H, and wherein alkyl is straight or branched chain C1-C6, aryl is a C6-C10 aromatic group, and aralkyl is a C1-C6 straight or branched chain alkyl-C6-C10 aromatic group.

2. The method of claim 1 wherein the antiviral compound is 9-(R)-(2-phosphonomethoxypropyl)adenine.
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Serving leading biopharmaceutical companies globally:

Federal Trade Commission
McKinsey
Chinese Patent Office
US Department of Justice
Cipla
Fish and Richardson
Farmers Insurance
Fuji
Argus Health
Novartis

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