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Summary for Patent: 6,057,305
|Title:||Antiretroviral enantiomeric nucleotide analogs|
|Abstract:||Resolved enantiomers of the formula ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.|
|Inventor(s):||Holy ; Antonin (Praha, CS), Dvorakova ; Hana (Praha, CS), DeClercq; Erik Desire Alice (Lovenjoel, BE), Balzarini; Jan Marie Rene (Heverlee, BE)|
|Assignee:||Institute of Organic Chemistry and Biochemistry of the Academy of (CZ) Rega Stichting, v.z.w. (BE)|
1. A method of achieving a human immunodeficiency virus or hepatitus B virus antiviral effect in a mammal in need of such treatment which comprises administering to said mammal an
antivirally effective amount of a compound of the formula ##STR13## including physiologically acceptable salts of such compound, wherein said compound of Formula IA is the R isomer substantially free of its enantiomer and wherein B is a purine moiety
substituted at the 6 position by amino, alkylamino, dialkylamino, or aralkylamino, and wherein R is H, and wherein alkyl is straight or branched chain C1-C6, aryl is a C6-C10 aromatic group, and aralkyl is a C1-C6 straight or branched chain alkyl-C6-C10
2. The method of claim 1 wherein the antiviral compound is 9-(R)-(2-phosphonomethoxypropyl)adenine.
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