Claims for Patent: 6,057,305

Summary for Patent: 6,057,305

Title:	Antiretroviral enantiomeric nucleotide analogs
Abstract:	Resolved enantiomers of the formula wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.
Inventor(s):	Antonin Holy, Hana Dvorakova, Erik Desire Alice DeClercq, Jan Marie Rene Balzarini
Assignee:	Stichting Rega VZW , Institute of Organic Chemistry and Biochemistry CAS
Application Number:	US07/925,610
Patent Claims:	1. A method of achieving a human immunodeficiency virus or hepatitus B virus antiviral effect in a mammal in need of such treatment which comprises administering to said mammal an antivirally effective amount of a compound of the formula ##STR13## including physiologically acceptable salts of such compound, wherein said compound of Formula IA is the R isomer substantially free of its enantiomer and wherein B is a purine moiety substituted at the 6 position by amino, alkylamino, dialkylamino, or aralkylamino, and wherein R is H, and wherein alkyl is straight or branched chain C1-C6, aryl is a C6-C10 aromatic group, and aralkyl is a C1-C6 straight or branched chain alkyl-C6-C10 aromatic group. 2. The method of claim 1 wherein the antiviral compound is 9-(R)-(2-phosphonomethoxypropyl)adenine.