|Title:||Orally administrable solid dosage form|
|Abstract:||An orally administrable solid dosage form containing a compacted ribavirin composition having an advantageously high tap density of at least 0.6 g/mL as well as surprisingly rapid disintegration and dissolution rates and wherein the ribavirin is subsantially free of polymorphic forms of ribavirin is disclosed.|
|Inventor(s):||Liebowitz; Stephen M. (Neshanic Station, NJ), Stupak; Elliot I. (West Caldwell, NJ), Chaudry; Imtiaz A. (North Caldwell, NJ), Vadino; Winston A. (Whitehouse Station, NJ), Bowen; Frank E. (Rutherford, NJ)|
|Assignee:||Schering Corporation (Kenilworth, NJ)|
1. A compacted ribavirin composition substantially free of other ribavirin polymorphic forms.
2. An orally administrable solid dosage form comprising a rapidly dissolving ribavirin compacted composition comprising ribavirin which is substantially free of other polymorphic forms of ribavirin.
3. An orally administrable solid dosage form comprising a rapidly dissolving ribavirin compacted composition comprising ribavirin and a pharmaceutically acceptable disintegrant wherein said composition has a tap density of at least about 0.6 g/mL and wherein more than about 80% by weight of the ribavirin dissolves in water in about 30, and wherein the ribavirin is substantially free of other polymorphic forms of ribavirin.
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