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Claims for Patent: 6,025,389

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Claims for Patent: 6,025,389

Title: Pharmaceutical and veterinary compositions of mupirocin and methods for their preparation
Abstract:The invention is directed to a pharmaceutical composition comprising a cream base which comprises mupiricin dihydrate, a mineral oil, one or more fatty alcohols or fatty esters, a polyoxyethylene ether or ester surfactant, xanthan gum, water and a method for treating a bacterial infection using said composition.
Inventor(s): Zimmerman; Harvey Lee (Bristol, TN)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Application Number:08/903,255
Patent Claims: 1. A pharmaceutical or veterinary composition comprising about 2.4% by weight of calcium mupirocin; about 50.9% by weight mineral oil USP; about 6% by weight polyethylene glycol monocetyl ether; about 3.5% by weight stearyl alcohol; about 3.5% by weight cetyl alcohol; about 0.5% by weight phenoxyethanol; about 1% by weight benzyl alcohol; about 0.2% by weight xanthan gum; and about 32% by weight purified water.

2. A method of treating bacterial infection, comprising the step of applying to a subject in need thereof a therapeutically effective amount of the composition as claimed in claim 1.

3. The composition as claimed in claim 1, wherein the calcium mupirocin is calcium mupirocin dihydrate.

4. A method of treating bacterial infection, comprising the step of applying to a subject in need thereof a therapeutically effective amount of the composition as claimed in claim 3.
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