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|Title:||Pharmaceutical and veterinary compositions of mupirocin and methods for their preparation|
|Abstract:||The invention is directed to a pharmaceutical composition comprising a cream base which comprises mupiricin dihydrate, a mineral oil, one or more fatty alcohols or fatty esters, a polyoxyethylene ether or ester surfactant, xanthan gum, water and a method for treating a bacterial infection using said composition.|
|Inventor(s):||Zimmerman; Harvey Lee (Bristol, TN)|
|Assignee:||SmithKline Beecham Corporation (Philadelphia, PA)|
1. A pharmaceutical or veterinary composition comprising about 2.4% by weight of calcium mupirocin; about 50.9% by weight mineral oil USP; about 6% by weight polyethylene glycol
monocetyl ether; about 3.5% by weight stearyl alcohol; about 3.5% by weight cetyl alcohol; about 0.5% by weight phenoxyethanol; about 1% by weight benzyl alcohol; about 0.2% by weight xanthan gum; and about 32% by weight purified water.
2. A method of treating bacterial infection, comprising the step of applying to a subject in need thereof a therapeutically effective amount of the composition as claimed in claim 1.
3. The composition as claimed in claim 1, wherein the calcium mupirocin is calcium mupirocin dihydrate.
4. A method of treating bacterial infection, comprising the step of applying to a subject in need thereof a therapeutically effective amount of the composition as claimed in claim 3.