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Claims for Patent: 6,008,228

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Claims for Patent: 6,008,228

Title: Pharmaceutical compositions containing proteinase inhibitors
Abstract:Compositions which increase the bioavailability of proteinase inhibitors are disclosed. Compositions which include a pharmaceutically acceptable carrier comprising monoglycerides of medium chain-fatty acids are preferred. Preferred medium chain fatty acid glycerides include monoglycerides of saturated C.sub.6 to C.sub.12 fatty acids, preferably C.sub.8 to C.sub.10 fatty acids The pharmaceutically acceptable carrier preferably has an acid value of less than or equal to about 2.5. Preferably, the ratio of monoglycerides of medium chain fatty acid to the proteinase inhibitor is about at least 1.5.
Inventor(s): Bailey; Carole Anne (Warren, NJ), Ferdinando; Josephine Christine (Chippenham, GB), Shah; Navnit (Clifton, NJ)
Assignee: Hoffman-La Roche Inc. (Nutley, NJ)
Application Number:08/616,233
Patent Claims: 1. A unit dose pharmaceutical composition comprising:

(a) an effective antiviral amount of of a compound having the formula N-tert-butyl-decahydro-2-[2(R)-hydroxy-4-phenyl-3-(S)-[[N-(2-quinolylcarbo nyl)-L-asparginyl]amino]butyl]-(4aS,8aS)-isoquinline-3-carboxamide, its pharmaceutically acceptable salts or esters (including their salts); and

(b) a mixture of glycerides which is about 40 to about 80% by weight of said composition; wherein said mixture of glycerides contains at least 70% monoglycerides of C.sub.8 -C.sub.10 medium chain fatty acids.

2. The composition of claim 1, wherein the weight ratio of monoglycerides in the mixture of glycerides in (b) to the effective amount of the compound in (a) is at least about 1.5.

3. The composition of claim 2, wherein the weight ratio of monoglycerides in the mixture of glycerides in (b) to the effective amount of the compound in (a) is from about 2.5 to about 3.5.

4. The composition of claim 3, wherein the mixture of glycerides in (b) has an acid value of less than about 2.5.

5. The composition of claim 4, further comprising dl-.alpha.-tocopherol.

6. The composition of claim 5, further comprising polyvinylpyrrolidone.

7. The composition of claim 1, wherein the mixture of glycerides in (b) contains about 83 to about 95% monoglycerides of C.sub.8 -C.sub.10 medium chain fatty acids.

8. The composition of claim 7, wherein the weight ratio of monoglycerides in the mixture of glycerides in (b) to the effective amount of the compound in (a) is at least about 1.5.

9. The composition of claim 8, wherein the weight ratio of monoglycerides in the mixture of glycerides in (b) to the effective amount of saquinavir in (a) is from about 2.5 to about 3.5.

10. The composition of claim 9, wherein the mixture of glycerides in (b) has an acid value of less than about 2.5.

11. The composition of claim 10, further comprising dl-.alpha.-tocopherol.

12. The composition of claim 11, further comprising polyvinylpyrrolidone.

13. The composition of claim 1, wherein the effective antiviral amount of the compound in (a) is from about 50 mg to about 400 mg.

14. The composition of claim 13, wherein the weight ratio of monoglycerides in the mixture of glycerides in (b) to the effective amount of the compound in (a) is at least about 1.5.

15. The composition of claim 14, wherein the effective antiviral amount of the compound in (a) is about 200 mg.

16. The composition of claim 15, wherein the weight ratio of monoglycerides in the mixture of glycerides in (b) to the effective amount of the compound in (a) is about 3.0.

17. The composition of claim 16, further comprising about 0.01 to about 0.5% dl .alpha.-tocopherol by weight of the composition.

18. The composition of claim 17, further comprising polyvinylpyrrolidone.

19. The composition of claim 18, wherein the composition comprises about 3% polyvinylpyrrolidone by weight of the composition.

20. The composition of claim 19, wherein the dl .alpha.-tocopherol is about 0.5% by weight of the composition.

21. The composition of claim 20, wherein the mixture of glycerides in (b) is about 76.5% of the composition by weight.

22. The composition of claim 21, wherein the mixture of glycerides is CAPMULMCM.

23. The composition of claim 22, wherein the unit dose is placed in a unit dosage form selected from the group consisting of soft gelatin capsules and hard gelatin capsules.

24. The composition of claim 23, wherein the unit dosage form is a soft gelatin capsule.

25. The composition of claim 1, wherein the unit dose is placed in a unit dosage form selected from the group of soft gelatin capsules and hard gelatin capsules.
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