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Claims for Patent: 6,006,745

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Claims for Patent: 6,006,745

Title: Device for delivering an aerosol
Abstract:A device for delivering an aerosol comprises a casing member, a valve stem, and a sealing member, wherein the sealing member comprises a thermoplastic elastomer comprising of a copolymer of about 80-95 mole % ethylene and about 5-20 mole % of at least one comonomer wherein the comonomer(s) are 1-butene, 1-hexene, or 1-octene. The device is used with pharmaceutical formulations containing 1,1,1,2-tetrafluoroethane and/or 1,1,1,2,3,3,3-heptafluoropropane as the propellant.
Inventor(s): Marecki; Paul E. (May Township, County of Washington, MN)
Assignee: Minnesota Mining and Manufacturing Company (St. Paul, MN)
Application Number:08/443,355
Patent Claims: 1. A device for delivering an aerosol, comprising: (i) an aerosol canister defining a formulation chamber having walls defining an aperture, and (ii) a thermoplastic elastomeric sealing member for minimizing and/or preventing escape of formulation components from said device, wherein the sealing member comprises a thermoplastic elastomer comprising a copolymer of about 80 to about 95 mole percent ethylene and a total of about 5 to about 20 mole percent of one or more comonomers selected from the group consisting of 1-butene, 1-hexene, and 1-octene and wherein said formulation chamber contains an aerosol formulation comprising 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane, or a mixture thereof, in an amount effective to function as a propellant.

2. A device according to claim 1, wherein the sole comonomer is 1-butene.

3. A device according to claim 1, wherein the thermoplastic elastomer comprises a copolymer of about 80 mole percent ethylene and about 20 mole percent 1-butene.

4. A device according to claim 1, wherein the sealing member is in the form of an O-ring.

5. A device according to claim 1, wherein the sealing member is in the form of a gasket.

6. A device according to claim 1, wherein the sealing member is in the form of a tank seal.

7. A device according to claim 1, wherein said formulation is a pharmaceutical formulation comprising 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane, or a mixture thereof, in an amount effective to function as an aerosol propellant, and a drug in an amount sufficient to provide a predetermined number of therapeutically effective doses for inhalation.

8. A device according to claim 7 wherein said drug is a bronchodilator or a steroid.

9. A device according to claim 7 wherein said drug is albuterol sulfate.

10. A device according to claim 7 wherein said drug is beclomethasone dipropionate.

11. A device according to claim 7 wherein said drug is pirbuterol acetate.

12. A device according to claim 7 wherein said formulation further comprises ethanol.

13. A device according to claim 1 further comprising: a tank seal having walls defining a tank seal aperture, and a metering tank of a predetermined volume and having an inlet end, an inlet aperture, and an outlet end, wherein the outlet end is in sealing engagement with the diaphragm, the valve stem passes through the inlet aperture and the tank seal aperture and is in slidable engagement with the tank seal aperture, and the tank seal is in sealing engagement with the inlet end of the metering tank, and wherein the valve stem is movable between an extended closed position, in which the inlet end of the metering tank is open and the outlet end is closed, and a compressed open position in which the inlet end of the metering tank is sealed and the outlet end is open to the ambient atmosphere.
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