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Last Updated: December 19, 2025

Claims for Patent: 6,004,565

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Summary for Patent: 6,004,565

Title:	Compositions and methods of using compositions with accelerated lymphocyte homing immunosuppressive properties
Abstract:	The methods and compositions of the invention and the compounds used in the invention involve a novel immunosuppression mechanism, accelerated lymphocyte homing immunosuppression (ALH-immunosuppression). For example, the compound FTY720 specifically directs lymphocytes to the peripheral lymph nodes, mesenteric lymph nodes, and Peyer's patches. By reversibly sequestering lymphocytes in these tissues, the compounds can inhibit an immune response in a mammal. Understanding these mechanisms provides a novel immunosuppression therapy that can synergistically interact with other immunosuppressive compounds. Screening methods for identifying similar ALH-immunosuppression compounds are also described. The invention allows better treatments and therapies wherever an immunosuppression regimen is desired.
Inventor(s):	Kenji Chiba, Kunitomo Adachi
Assignee:	Mitsubishi Tanabe Pharma Corp
Application Number:	US08/933,738
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 6,004,565
Patent Claims:

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