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|Title:||Compositions and methods of using compositions with accelerated lymphocyte homing immunosuppressive properties|
|Abstract:||The methods and compositions of the invention and the compounds used in the invention involve a novel immunosuppression mechanism, accelerated lymphocyte homing immunosuppression (ALH-immunosuppression). For example, the compound FTY720 specifically directs lymphocytes to the peripheral lymph nodes, mesenteric lymph nodes, and Peyer's patches. By reversibly sequestering lymphocytes in these tissues, the compounds can inhibit an immune response in a mammal. Understanding these mechanisms provides a novel immunosuppression therapy that can synergistically interact with other immunosuppressive compounds. Screening methods for identifying similar ALH-immunosuppression compounds are also described. The invention allows better treatments and therapies wherever an immunosuppression regimen is desired.|
|Inventor(s):||Chiba; Kenji (Fukuoka, JP), Adachi; Kunitomo (Fukuoka, JP)|
|Assignee:||Yoshitomi Pharmaceutical Industries, Ltd. (Osaka, JP)|
1. A method for accelerating the lymphocyte homing activity of the immune system of a mammal, while simultaneously maintaining the IL-2 mRNA expressing ability of T cells in
the mammal, comprising introducing an effective amount of an accelerated lymphocyte homing composition comprising 2-amino-2[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride to the mammal.
2. A method for reversibly reducing the number of circulating lymphocytes in a mammal other than rat or dog, comprising introducing an effective amount of an accelerated lymphocyte homing composition comprising 2-amino-2[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride or to the mammal, wherein a measurable amount of the circulating lymphocytes are directed to peripheral or mesenteric lymphoid tissue.
3. A method of manipulating lymphocyte traffic in a mammal comprising administering a composition comprising an effective amount of an accelerated lymphocyte homing compound comprising 2-amino-2[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride.
4. The method according to claim 1, wherein the lymphocyte homing is to mesenteric or peripheral lymphoid tissue.
5. The method according to claim 1, wherein the lymphocyte homing is to Peyer's patches.
6. The method according to claim 1, wherein the introducing is by oral administration.
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