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Claims for Patent: 5,990,176

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Claims for Patent: 5,990,176

Title: Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid
Abstract:The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.
Inventor(s): Bieniarz; Christopher (Highland Park, IL), Chang; Steve H. (Gurnee, IL), Cromack; Keith R. (Lake Bluff, IL), Huang; Shuyen L. (Riverwoods, IL), Kawai; Toshikazu (Tsurugashima, JP), Kobayashi; Manami (Miyoshimachi, JP), Loffredo; David (Elmhurst, IL), Raghavan; Rajagopalan (Grayslake, IL), Speicher; Earl R. (Buffalo Grove, IL), Stelmach; Honorate A. (Lake Forest, IL)
Assignee: Abbott Laboratories (Abbott Park, IL) Central Glass Company Ltd. (Tokyo, JP)
Application Number:08/789,679
Patent Claims: 1. An anesthetic composition comprising:

a quantity of sevoflurane; and

a Lewis acid inhibitor in an amount effective to prevent degradation by a Lewis acid of said quantity of sevoflurane, said Lewis acid inhibitor selected from the group consisting of water, butylated hydroxytoluene, methylparaben, propylparaben, propofol, and thymol.

2. The composition of claim 1 wherein the Lewis acid inhibitor is water.

3. The composition of claim 2 containing at least about 0.04% w/w to about 0.14% w/w of water.

4. A method of preparing the anesthetic composition of claim 1 comprising the step of adding the Lewis acid inhibitor to said quantity of sevoflurane.

5. A method of preparing the anesthetic composition of claim 1 comprising the step of adding said quantity of sevoflurane, to the Lewis acid inhibitor.

6. A method of preventing degradation by a Lewis acid of a quantity of sevoflurane, the method comprising the steps of:

providing a quantity of sevoflurane;

providing a Lewis acid inhibitor in an amount sufficient to prevent degradation by a Lewis acid of said quantity of sevoflurane, said Lewis acid inhibitor selected from the group consisting of water, butylated hydroxytoluene, methylparaben, propylparaben, propofol, and thymol;

combining said quantity of sevoflurane and the Lewis acid inhibitor in an amount sufficient to prevent the degradation by a Lewis acid of said quantity of sevoflurane.

7. The method of claim 6 wherein the Lewis acid inhibitor is water.

8. The method of claim 2 wherein the amount of water added to the sevoflurane is from about 0.04% w/w to about 0.14% w/w.

9. An anesthetic composition comprising:

a quantity of sevoflurane; and

water in an amount effective to prevent degradation by a Lewis acid of said quantity of sevoflurane.

10. A method of preventing degradation by a Lewis acid of a quantity of sevoflurane, the method comprising the steps of:

providing a quantity of sevoflurane;

providing water in an amount sufficient to prevent degradation by a Lewis acid of said quantity of sevoflurane;

combining said quantity of sevoflurane and said water in an amount sufficient to prevent the degradation by a Lewis acid of said quantity of sevoflurane.
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