|Title:|| Copolymer-1 improvements in compositions of copolymers|
|Abstract:||The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.|
|Inventor(s):|| Konfino; Eliezer (Ramat Gan, IL), Sela; Michael (Rehovot, IL), Teitelbaum; Dvora (Rehovot, IL), Arnon; Ruth (Rehovot, IL) |
|Assignee:|| Yeda Research and Development Co., Ltd. (Rehovot, IL) |
1. Copolymer-1 having a molecular weight of about 5 to 9 kilodaltons, made by a process comprising the steps of:
reacting protected copolymer-1 with hydrobromic acid to form trifluoroacetyl copolymer-1,
treating said trifluoroacetyl copolymer-1 with aqueous piperidine solution to form copolymer-1, and
purifying said copolymer-1, to result in copolymer-1 having a molecular weight of about 5 to 9 kilodaltons.