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Last Updated: April 26, 2024

Claims for Patent: 5,972,882

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Summary for Patent: 5,972,882

Title:	Treatment of polycystic kidney disease using vasopressin V.sub.2 receptor antagonists
Abstract:	The present invention is directed to the novel treatment of ARPKD and ADPKD by administering a pharmacologically effective amount of a V.sub.2 receptor antagonist. Orally active V.sub.2 receptor antagonists such as OPC-31260, OPC-41061, SR121463A and VPA-985 are administered alone, or in combination to mammalian PKD subjects to reduce the cAMP generated by the increased expression of AVP-V.sub.2 receptor, AQP2 and AQP3, thereby reducing and/or preventing cyst enlargement.
Inventor(s):	Gattone, II; Vincent H. (Overland Park, KS)
Assignee:	University of Kansas Medical Center (Kansas City, KS)
Application Number:	09/211,396
Patent Claims:	1. A method for treating polycystic kidney disease in a mammal comprising administering a therapeutically effective amount of a vasopressin V.sub.2 receptor antagonist to said mammal. 2. The method of claim 1 wherein said vasopressin V.sub.2 receptor antagonist is selected from the group consisting of OPC-31260, OPC-41061, SR121463A, VPA-985 and peptide V.sub.2 antagonists. 3. The method of claim 1 wherein said vasopressin V.sub.2 receptor antagonist is OPC-31260 administered orally to said mammal in a dose of about 60 mg/kg/day. 4. The method of claim 1 wherein said vasopressin V.sub.2 receptor antagonist is SR121463A administered orally to said mammal in a dose of about 2 mg/kg/day. 5. The method of claim 1 wherein said vasopressin V.sub.2 receptor antagonist is VPA-985 administered orally to said mammal in a dose of about 2 mg/kg/day. 6. A method for attenuating azotemia and cyst enlargement in polycystic kidney disease in a mammal comprising administering a therapeutically effective amount of a vasopressin V.sub.2 receptor antagonist selected from the group consisting of OPC-31260, OPC-41061, SR121463A, VPA-9835 and peptide V.sub.2 antagonists. 7. The method of claim 6 wherein said vasopressin V.sub.2 receptor antagonist is OPC-31260 administered orally to said mammal in a dose of about 60 mg/kg/day. 8. The method of claim 6 wherein said vasopressin V.sub.2 receptor antagonist is SR121463A administered orally to said mammal in a dose of about 2 mg/kg/day. 9. The method of claim 6 wherein said vasopressin V.sub.2 receptor antagonist is VPA-985 administered orally to said mammal in a dose of about 2 mg/kg/day.

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