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Claims for Patent: 5,968,976

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Claims for Patent: 5,968,976

Title: Pharmaceutical composition containing selected lanthanum carbonate hydrates
Abstract:Selected lanthanum carbonate hydrates may be administered into the gastrointestinal tract, to treat hyperphosphataemia in patients with renal failure.
Inventor(s): Murrer; Barry A (Berkshire, GB), Powell; Nigel A (Berkshire, GB)
Assignee: AnorMed Inc. (Langley, CA)
Application Number:08/913,960
Patent Claims: 1. A pharmaceutical composition for the treatment of hyperphosphataemia comprising lanthanum carbonate of the formula

where x has a value from 3 to 6, in admixture with a pharmaceutically acceptable diluent or carrier in a form for administration to the gastrointestinal tract.

2. A composition according to claim 1, wherein x has a value from 3.5 to 5.

3. A composition according to claim 2, wherein x has a value from 3.8 to 4.5.

4. A composition according to any one of claims 1 to 3 in unit dosage form to provide from 0.1 to 20 g/day.

5. A process for the preparation of lanthanum carbonate as defined in any one of claims 1 to 3 which comprises the steps of:

(i) reacting lanthanum oxide with hydrochloric acid to obtain lanthanum chloride;

(ii) reacting a solution of the thus obtained lanthanum chloride with an alkali metal carbonate to produce a wet cake of lanthanum carbonate octahydrate; and

(iii) drying the wet cake of lanthanum carbonate octahydrate so as to obtain a lanthanum carbonate with 3 to 6 molecules of water of crystallisation.

6. A process as claimed in claim 5 wherein the alkali metal carbonate is sodium carbonate.

7. A method to treat hyperphosphataemia in a subject which method comprises administering to said subject an amount of lanthanum carbonate of the formula

wherein x has a value from 3 to 6 effective to treat said hyperphosphataemia.

8. The method of claim 7 wherein x has a value from 3.5 to 5.

9. The method of claim 8 wherein x has a value from 3.8 to 4.5.

10. The method of any of claims 7-9 wherein said administering is by an oral route.
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