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|Title:||Enantiomer of carbazole derivative as 5-HT1-like agonists|
|Abstract:||A (+) or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate, or hydtrate thereof, processes for preparing said compounds and pharmaceutical compostions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.|
|Inventor(s):||Borrett; Gary Thomas (Stansted, GB), Kitteringham; John (Hertford, GB), Porter; Roderick Alan (Ashwell, GB), Shipton; Mark Ralph (Hertfordshire, GB), Vimal; Mythily (Edmonton, GB), Young; Rodney Christopher (Oxford, GB)|
|Assignee:||SmithKline Beecham, p.l.c. (Brentford Middlesex, GB)|
1. (+)-6-Carboxamido-3-N-methylamino-1,2,3,4-tetrahydrocarbazole succinate monohydrate.
2. A pharmaceutical composition comprising the compound according to claim 1 and a physiologically acceptable carrier.
3. A method of treatment of a condition wherein a 5-HT.sub.1 -like agonist is indicated, which comprises administering to a subject in need thereof an effective amount of the compound according to claim 1.
4. The method of treatment according to claim 3, wherein the condition is migraine.
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