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Claims for Patent: 5,958,915

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Claims for Patent: 5,958,915

Title: Antibacterial composition for oral administration
Abstract:A new, antibacterial composition for use in oral administration is now provided, which composition comprises a mixture of Cefditoren pivoxyl with a water soluble casein salt. This composition has a reduced bitter taste of Cefditoren pivoxyl and also has improved properties regarding the rate and concentration of dissolution of Cefditoren pivoxyl in water and a ratio of dissolution out of Cefditoren pivoxyl into water. This composition further can attain a high absorbability of the Cefditoren component at the digestive tubes upon oral administration thereof. In this composition, the ratio (by weight) of Cefditoren pivoxyl to the casein salt added may preferably be in a range of 1:0.1 to 1:4. By further addition of a water-soluble polyphosphoric acid salt to the composition, the composition can prevent a ratio of dissolution out into water of the Cefditoren pivoxyl component being decreased when the composition was stored under severe conditions.
Inventor(s): Abe; Kenichi (Yokohama, JP), Ota; Masato (Yokohama, JP), Yamaguchi; Hiroyuki (Yokohama, JP), Murakami; Chikako (Kawasaki, JP), Kikkoji; Toshihiro (Yokohama, JP)
Assignee: Meiji Seika Kaisha, Ltd. (JP)
Application Number:09/051,318
Patent Claims: 1. An antibacterial composition of Cefditoren pivoxyl for use in oral administration and having a reduced bitter taste and having an enhanced dispersibility of the composition in water and an enhanced rate of dissolution of Cefditoren pivoxyl component in water, characterised in that the composition comprises a mixture of Cefditoren pivoxyl with a proportion of a pharmaceutically acceptable and water-soluble casein salt.

2. The composition as claimed in claim 1, in which the casein salt is sodium caseinate or potassium caseinate.

3. The composition as claimed in claim 1, in which the ratio by weight of Cefditoren pivoxyl to the casein salt is in a range of 1:0.1 to 1:4.

4. The composition as claimed in claim 3, in which the ratio by weight of Cefditoren pivoxyl to the casein salt is in a range of 1:0.4 to 1:2.

5. The composition as claimed in claim 1, which further contains one or more additives chosen from pharmaceutically acceptable excipients and disintegrators.

6. The composition as claimed in claim 1, which is prepared in the form of granules, fine granules or tablets.

7. An antibacterial composition of Cefditoren pivoxyl for use in oral administration and having a reduced bitter taste and having an enhanced dispersibility of the composition and an enhanced rate of dissolution of the Cefditoren pivoxyl component in water and also capable of maintaining a high rate of disolution of the Cefditoren pivoxyl component into water after storage of the composition at an elevated temperature, characterized in that the composition comprises a mixture of Cefditoren pivoxyl with a proportion of a pharamceutically acceptable and water-soluble casein salt and a proportion of a pharmaceutically acceptable and water-soluble polyphosphoric acid salt.

8. The composition as claimed in claim 7, in which the casein salt is sodium caseinate or potassium caseinate and the polyphosphoric acid salt is sodium or potassium polyphosphate.

9. The composition as claimed in claim 8, in which the sodium or potassium polyphosphate is a pure sodium or potassium tri-polyphosphate, or a commercially available sodium or potassium polyphosphate.

10. The composition as claimed in claim 7, in which the ratio by weight of the casein salt to polyphosphoric acid salt is in a range of 1:0.02 to 1:0.06.

11. The composition as claimed in claim 7, in which the ratio by weight of Cefditoren pivoxyl to the casein salt is in a range of 1:0.1 to 1:4.

12. The composition as claimed in claim 7, which further contains one or more additives chosen from pharmaceutically acceptable excipients and disintegrators and is prepared in the form of granules, fine granuels or tablets.

13. The composition as claimed in claim 7, in which the ratio by weight of the casein salt to polyphosphoric acid salt is in a range of 1:0.02 to 1:0.05.

14. A method for reducing the bitter taste of Cefditoren pivoxyl and enhancing the rate of dissolution of Cefditoren pivoxyl into water, as well as the concentration of Cefditoren pivoxyl attainable by its dissolution into water for a predetermined period of time, which method comprises mixing Cefditoren pivoxyl with a proportion of a pharmaceutically acceptable and water-soluble casein salt at a ratio by weight of Cefditoren pivoxyl to the casein salt in a range of 1:0.1 to 1:4 and thereby forming a uniform mixture of Cefditoren pivoxyl with the casein salt.

15. The method as claimed in claim 14, in which the casein salt is sodium caseinate or potassium caseinate.

16. The method as claimed in claim 14, in which Cefditoren pivoxyl is mixed with the casein salt in a range of 1:0.4 to 1:2.
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