|Title:|| Method for in vivo modulation of non-malignant skin-related processes with 9-cis-retinoic acid|
|Abstract:||A method for modulating non-malignant skin related disorders in a subject has been demonstrated with 9-cis retinoic acid. Wrinkling, acne, keratinization, differentiation and proliferation disorders are treated by administration of 9-cis retinoic acid alone or in a pharmaceutically acceptable carrier to a subject in need thereof.|
|Inventor(s):|| Evans; Ronald M. (La Jolla, CA), Mangelsdorf; David J. (Dallas, TX), Heyman; Richard A. (Encinitas, CA), Boehm; Marcus F. (San Diego, CA), Eichele; Gregor (Houston, TX), Thaller; Christina (Houston, TX) |
|Assignee:|| The Salk Institute for Biological Studies (La Jolla, CA) Baylor College of Medicine (Houston, TX) Ligand Pharmaceuticals, Inc. (San Diego, CA) |
1. A method for in vivo modulation of a non-malignant skin disorder in a subject, wherein said non-malignant skin disorder is selected from the group consisting of
aging, wrinkingling, acne, keratinization, differentiation, and proliferation disorders,
said method comprising administering to said subject an effective amount of 9-cis-retinoic acid or pharmaceutically acceptable carriers containing same.
2. A method for in vivo modulation of the development of benign tumors in the skin of a subject, said method comprising administering to said subject an effective amount of 9-cis-retonic acid or pharmaceutically acceptable carriers containing