Last Updated: May 10, 2026

Claims for Patent: 5,932,622


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Summary for Patent: 5,932,622
Title:Method for in vivo modulation of non-malignant skin-related processes with 9-cis-retinoic acid
Abstract:A method for modulating non-malignant skin related disorders in a subject has been demonstrated with 9-cis retinoic acid. Wrinkling, acne, keratinization, differentiation and proliferation disorders are treated by administration of 9-cis retinoic acid alone or in a pharmaceutically acceptable carrier to a subject in need thereof.
Inventor(s):Ronald M. Evans, David J. Mangelsdorf, Richard A. Heyman, Marcus F. Boehm, Gregor Eichele, Christina Thaller
Assignee: Baylor College of Medicine , Salk Institute for Biological Studies , Eisai Inc
Application Number:US08/475,174
Patent Claims: 1. A method for in vivo modulation of a non-malignant skin disorder in a subject, wherein said non-malignant skin disorder is selected from the group consisting of aging, wrinkingling, acne, keratinization, differentiation, and proliferation disorders,said method comprising administering to said subject an effective amount of 9-cis-retinoic acid or pharmaceutically acceptable carriers containing same.

2. A method for in vivo modulation of the development of benign tumors in the skin of a subject, said method comprising administering to said subject an effective amount of 9-cis-retonic acid or pharmaceutically acceptable carriers containing same.

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