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Claims for Patent: 5,932,622

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Claims for Patent: 5,932,622

Title: Method for in vivo modulation of non-malignant skin-related processes with 9-cis-retinoic acid
Abstract:A method for modulating non-malignant skin related disorders in a subject has been demonstrated with 9-cis retinoic acid. Wrinkling, acne, keratinization, differentiation and proliferation disorders are treated by administration of 9-cis retinoic acid alone or in a pharmaceutically acceptable carrier to a subject in need thereof.
Inventor(s): Evans; Ronald M. (La Jolla, CA), Mangelsdorf; David J. (Dallas, TX), Heyman; Richard A. (Encinitas, CA), Boehm; Marcus F. (San Diego, CA), Eichele; Gregor (Houston, TX), Thaller; Christina (Houston, TX)
Assignee: The Salk Institute for Biological Studies (La Jolla, CA) Baylor College of Medicine (Houston, TX) Ligand Pharmaceuticals, Inc. (San Diego, CA)
Application Number:08/475,174
Patent Claims: 1. A method for in vivo modulation of a non-malignant skin disorder in a subject, wherein said non-malignant skin disorder is selected from the group consisting of aging, wrinkingling, acne, keratinization, differentiation, and proliferation disorders,

said method comprising administering to said subject an effective amount of 9-cis-retinoic acid or pharmaceutically acceptable carriers containing same.

2. A method for in vivo modulation of the development of benign tumors in the skin of a subject, said method comprising administering to said subject an effective amount of 9-cis-retonic acid or pharmaceutically acceptable carriers containing same.
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