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Summary for Patent: 5,922,338
|Title:||Polyol esters, their preparation and use in depot forms of pharmacologically active agents|
|Abstract:||This invention provides a polyester of a polyol, said polyol containing at least 3 hydroxyl groups and having a molecular weight of up to 20,000 at least 1 hydroxyl group in said polyol being in the form of an ester, with a poly- or co-poly-lactic acid residue, each having a molecular weight of at least from 5,000. These are useful for parenteral depot formulations.|
|Inventor(s):||Brich; Zdenek (Binningen, CH), Kissel; Thomas (Ehrenkirchen, DE)|
|Assignee:||Novartis AG (Basel, CH)|
1. A branched polyglycolide lactide ester of glucose, having a molecular weight of from 20,000 to 200,000.
2. The ester of glucose of claim 1 having a molecular weight of 20,000 to 80,000.
3. A formulation comprising a matrix of said ester of glucose of claim 1 and a therapeutically effective amount of a pharmacologically active agent.
4. A formulation of claim 3 wherein said active agent is selected from the group consisting of bromocriptine, ketotifen and co-dergocrine.
5. A formulation of claim 3 wherein said formulation is in implant form.
6. A formulation of claim 3 wherein said formulation is in microcapsule form.
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