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Claims for Patent: 5,917,054

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Claims for Patent: 5,917,054

Title: Process for preparing enantiomers of carbazole derivatives as 5-HT.sub.1 -like agonists
Abstract:A (+) or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists. ##STR1##
Inventor(s): Borrett; Gary Thomas (Stansted, GB), Kitteringham; John (Hertford, GB), Porter; Roderick Alan (Ashwell, GB), Shipton; Mark Ralph (Bishop's Stortford, GB), Vimal; Mythily (Edmonton, GB), Young; Rodney Christopher (Oxford, GB)
Assignee: SmithKline Beecham p.l.c. (Brentford, GB)
Application Number:08/781,990
Patent Claims: 1. A process for preparing an enantiomer of formula (I) ##STR7## wherein R.sup.4 is methyl or ethyl, or a salt, solvate or hydrate thereof which comprises alkylating a (+) or (-) enantiomer of 3-amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole or a salt thereof, followed if necessary or desired by removal of any N-protecting group, conversion of a salt into a free base and/or salt formation.
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