.

BioPharmaceutical Business Intelligence

  • Analyze global market entry opportunities
  • Uncover prior art in expired and abandoned patents
  • Obtain formulation and manufacturing information

► See Plans & Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

Covington
Teva
Deloitte
Fuji
Medtronic
McKesson
Express Scripts
Cantor Fitzgerald
Colorcon
Julphar

Generated: September 25, 2017

DrugPatentWatch Database Preview

Claims for Patent: ► Subscribe

« Back to Dashboard

Claims for Patent: ► Subscribe

Title: HMG co-reductase inhibitor
Abstract:A controlled release dosage formulation is described which is based on a combination of: (a) a compressed tablet core which contains an alkyl ester of a hydroxy substituted naphthalene derivative a pharmaceutically acceptable, water swellable polymer and an osmotic agent; and (b) an outer coating layer which completely covers the osmotic core and comprises a pH sensitive coating agent and a water insoluble polymer.
Inventor(s): Chen; Chih-Ming (Davie, FL), Chou; Joseph (Coral Springs, FL), Wong; David (Hollywood, FL)
Assignee: Andrx Pharmaceutials, Inc. (Fort Lauderdale, FL)
Application Number:08/989,253
Patent Claims: 1. A controlled release formulation containing an alkyl ester of a hydroxy substituted naphthalene compound, said formulation comprising:

(a) a compressed tablet core which contains an alkyl ester of a hydroxy substituted naphthalene compound, a pharmaceutically acceptable, water swellable polymer and an osmotic agent; and

(b) an outer coating layer which completely covers the osmotic core and comprises a pH sensitive coating agent, a channeling agent and a water insoluble cellulosic polymer used at a weight ratio of 0.1:1 to 0.75:1 and at a combined coating weight of 0.5-5% by weight.

2. A controlled release formulation as defined in claim 1 wherein the alkyl ester of a hydroxy substituted naphthalene compound is selected from the group consisting of mevastatin, pravastatin, simvastatin and lovastatin.

3. A controlled release dosage form as defined in claim 2 wherein said compressed tablet core is provided with a first coating to seal the tablet core.

4. A controlled release dosage form as defined in claim 2 wherein said compressed tablet core is provided with an inner enteric coating.

5. A controlled release dosage form as defined in claim 2 wherein said compressed tablet core is provided with an overcoat which is an enteric coating.

6. A controlled release dosage form as defined in claim 2 wherein the pharmaceutically acceptable water swellable polymer is polyethylene oxide.

7. A controlled release dosage form as defined in claim 2 wherein the osmotic agent is anhydrous lactose.

8. A controlled release dosage form as defined in claim 2 wherein the pH sensitive coating agent is a copolymer of poly(methacrylic acid and methylmethacrylate.

9. A controlled release dosage form as defined in claim 2 wherein the tablet core contains a surface active agent.

10. A controlled release dosage form as defined in claim 2 wherein the tablet core contains sodium lauryl sulfate.

11. A controlled release dosage form which comprises:

(a) a compressed tablet core which comprises lovastatin, a polyoxyethylene water swellable polymer and anhydrous lactose;

(b) an outer coating layer which comprises a mixture of a copolymer of poly(methacrylic acid/methylmethacrylate and a cellulose acetate polymer at a weight ratio of 0.1:1 to 0.75:1.

12. A controlled release dosage formulation which comprises:

(a) a compressed tablet core comprising lovastatin, a pharmaceutically acceptable, water swellable polymer and an osmotic agent;

(b) an inner coating layer which comprises a pH sensitive coating agent; and

(c) an outer coating layer which comprises a pH sensitive coating agent, a channeling agent and a water insoluble cellulosic polymer.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Boehringer Ingelheim
Express Scripts
Argus Health
Johnson and Johnson
Fuji
Covington
US Department of Justice
Moodys
Chinese Patent Office
McKesson

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted Heap | Mobile and Web Analytics
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot