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Last Updated: December 12, 2025

Claims for Patent: 5,908,638

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Summary for Patent: 5,908,638

Title:	Pharmaceutical compositions of conjugated estrogens and methods for their use
Abstract:	This invention relates to novel pharmaceutical compositions and methods for their preparation containing conjugated estrogens for the treatment of peri-menopausal, menopausal and post-menopausal disorders in women. The novel pharmaceutical compositions comprise a carrier base material and conjugated estrogens formed into a solid unit dosage form possessing a regular incremental release of the medicament upon oral administration. Further, the invention comprises the combination of conjugated estrogens with progestogens in a solid, shaped dosage unit. Specifically, the invention comprises the use of an organic excipient such as high molecular weight hydroxyalkyl alkylcelluloses. The use of an organic excipient such as hydroxypropylmethylcellulose in a stable, solid dosage formulation containing either conjugated estrogens alone or in combination with a progestogen is described.
Inventor(s):	Harold Eugene Huber, Mary Katherine Ryan
Assignee:	Teva Womens Health Inc
Application Number:	US08/690,407
Patent Claims:

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