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|Title:||Method for treating mycosis using imidazolylacetonitrile derivatives|
|Abstract:||R-(+)-(E)-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylacetonit rile, R-(-)-(E)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylace tonitrile, and pharmaceutically acceptable salts thereof which can be used as a pharmaceutical agent are disclosed. A process for producing them and a method for treating mycoses using them are also disclosed.|
|Inventor(s):||Kodama; Hiroki (Osaka, JP), Niwano; Yoshimi (Osaka, JP), Kanai; Kazuo (Osaka, JP), Yoshida; Masanori (Wakayama, JP)|
|Assignee:||Nihon Nohyaku Co., Ltd. (Tokyo, JP)|
1. R-(-)-(E)-[ 4-(2,4-Dichlorophenyl)-1,3-dithilan-2-ylidene]-1-imidazolylacetonitrile or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising as an active ingredient R-(-)-(E)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylace tonitrile, or a pharmaceutically acceptable salt thereof; together with a pharmaceutically acceptable carrier or diluent.
3. A process for producing R-(-)-(E)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylace tonitrile represented by formula (B): ##STR16## which comprises reacting an optically active glycol derivative represented by formula (II) with a dithiolate salt represented by formula (III): ##STR17## wherein X.sub.1 and X.sub.2 are the same or different and each represents a methanesulfonyloxy group, a benzenesulfonyloxy group, a p-toluenesulfonyloxy group, or a halogen atom: ##STR18## wherein M represents an alkali metal atom.
4. A method for preventing or treating mycosis which comprises administrating to a human or animal in need of such prevention or treatment, a pharmaceutically effective amount of R-(-)-(E)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylace tonitrile, or a pharmaceutical acceptable salt thereof.
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