Deeper Knowledge, Faster

  • Identify first generic entrants
  • Uncover prior art in expired and abandoned patents
  • Drug patents in 130+ countries

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

Chinese Patent Office
Harvard Business School

Generated: November 17, 2017

DrugPatentWatch Database Preview

Claims for Patent: 5,900,488

« Back to Dashboard

Claims for Patent: 5,900,488

Title: Method for treating mycosis using imidazolylacetonitrile derivatives
Abstract:R-(+)-(E)-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylacetonit rile, R-(-)-(E)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylace tonitrile, and pharmaceutically acceptable salts thereof which can be used as a pharmaceutical agent are disclosed. A process for producing them and a method for treating mycoses using them are also disclosed.
Inventor(s): Kodama; Hiroki (Osaka, JP), Niwano; Yoshimi (Osaka, JP), Kanai; Kazuo (Osaka, JP), Yoshida; Masanori (Wakayama, JP)
Assignee: Nihon Nohyaku Co., Ltd. (Tokyo, JP)
Application Number:08/981,420
Patent Claims: 1. R-(-)-(E)-[ 4-(2,4-Dichlorophenyl)-1,3-dithilan-2-ylidene]-1-imidazolylacetonitrile or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising as an active ingredient R-(-)-(E)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylace tonitrile, or a pharmaceutically acceptable salt thereof; together with a pharmaceutically acceptable carrier or diluent.

3. A process for producing R-(-)-(E)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylace tonitrile represented by formula (B): ##STR16## which comprises reacting an optically active glycol derivative represented by formula (II) with a dithiolate salt represented by formula (III): ##STR17## wherein X.sub.1 and X.sub.2 are the same or different and each represents a methanesulfonyloxy group, a benzenesulfonyloxy group, a p-toluenesulfonyloxy group, or a halogen atom: ##STR18## wherein M represents an alkali metal atom.

4. A method for preventing or treating mycosis which comprises administrating to a human or animal in need of such prevention or treatment, a pharmaceutically effective amount of R-(-)-(E)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylace tonitrile, or a pharmaceutical acceptable salt thereof.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving leading biopharmaceutical companies globally:

Farmers Insurance
Argus Health
Queensland Health
Harvard Business School
US Department of Justice

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:

Google Plus