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Claims for Patent: 5,898,032

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Claims for Patent: 5,898,032

Title: Ultra low dose oral contraceptives with less menstrual bleeding and sustained efficacy
Abstract:A method of female contraception involves administering a combination of estrogen and progestin for 60-110 consecutive days in which the daily amounts of estrogen and progestin are equivalent to about 5-35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethindrone acetate, respectively. The advantages include less menstrual bleeding, less patient anemia, less total exposure to medication, higher compliance rates and more lifestyle convenience for patients.
Inventor(s): Hodgen; Gary D. (Virginia Beach, VA)
Assignee: Medical College of Hampton Roads (Norfolk, VA)
Application Number:08/880,419
Patent Claims: 1. A method of female contraception which comprises monophasicly administering to a pre-menopausal female a combination of estrogen and progestin for 60-110 consecutive days in which the daily amounts of estrogen and progestin are equivalent to about 5-35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethindrone acetate, respectively, following by non-administration for a period of 3-10 days.

2. The method of claim 1 in which the daily amount of estrogen is equivalent to about 10 to 20 mcg of ethinyl estradiol.

3. The method of claim 2 in which the daily amount of progestin is equivalent to 0.25-1.5 mg of norethindrone acetate.

4. The method of claim 3 in which the combination is administered for at least 80 consecutive days.

5. The method of claim 4 in which the estrogen is ethinyl estradiol.

6. The method of claim 5 in which the progestin is norethindrone acetate.

7. The method of claim 1 in which the daily amount of progestin is equivalent to 0.25-1.5 mg of norethindrone acetate.

8. The method of claim 1 in which the combination is administered for at least 80 consecutive days.

9. The method of claim 1 in which the estrogen is ethinyl estradiol.

10. The method of claim 1 in which the progestin is norethindrone acetate.

11. The method of claim 1 in which the daily amount of estrogen is up to 30 mcg of ethinyl estadiol.
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