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Claims for Patent: 5,886,039

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Claims for Patent: 5,886,039

Title: Method and composition for treating erectile dysfunction
Abstract:Lipophilic active substance composition and its use in a new method of treating erectile dysfunction by administration thereof, optionally together with a hydrophilic vehicle and optionally an antibacterial agent into the urethra.
Inventor(s): Kock; Nils G. (Goteborg, SE), Lycke; Gerhard (Vastra Frolunda, SE)
Assignee:
Application Number:08/485,041
Patent Claims: 1. A method for treating erectile dysfunction in a male individual, comprising:

(a) providing a pharmaceutical composition comprising a lipophilic active agent selected from the group consisting of vasoactive prostaglandins; and

(b) administering to the urethra of the individual an amount of the composition containing a therapeutic dosage of the active agent effective to produce penile erection following urethral administration.

2. The method of claim 1, wherein the lipophilic active agent is selected from the group consisting of prostaglandin E.sub.1, prostaglandin E.sub.2, prostaglandin F.sub.2, and combinations thereof.

3. The method of claim 2, wherein the lipophilic active agent is prostaglandin E.sub.1.

4. The method of claim 2, wherein the lipophilic active agent is prostaglandin E.sub.2.

5. The method of claim 2, wherein the lipophilic active agent is prostaglandin F.sub.2.

6. The method of claim 2, wherein the lipophilic active agent comprises a mixture of prostaglandin E.sub.1 and prostaglandin E.sub.2.

7. The method of claim 1, wherein the composition further comprises a hydrophilic vehicle.

8. The method of claim 7, wherein the hydrophilic vehicle is selected to facilitate passage of the lipophilic active agent through the urethral membrane.

9. The method of claim 8, wherein the hydrophilic vehicle comprises a fat-free cream.

10. The method of claim 8, wherein the hydrophilic vehicle comprises a fat-free ointment.

11. The method of claim 8, wherein the hydrophilic vehicle comprises a macrogol.

12. The method of claim 1, wherein the composition further comprises an additional active agent selected from the group consisting of .alpha.-blockers, vasoactive intestinal polypeptide and nitroglycerine.

13. The method of claim 12, wherein the additional active agent is an .alpha.-blocker.

14. The method of claim 13, wherein the .alpha.-blocker is selected from the group consisting of phentolamine, phenoxybenzamine, prazosin, and combinations thereof.

15. The method of claim 14, wherein the .alpha.-blocker is phentolamine.

16. The method of claim 14, wherein the .alpha.-blocker is phenoxybenzamine.

17. The method of claim 14, wherein the .alpha.-blocker is prazosin.

18. The method of claim 1, wherein the composition further comprises an antibacterial agent.

19. The method of claim 1, wherein the composition is administered via instillation into the urethra.

20. A pharmaceutical composition for urethral drug administration, comprising a lipophilic active agent dispersed in a hydrophilic vehicle, wherein:

(a) the hydrophilic vehicle is (i) suitable for urethral administration, (ii) effective to facilitate passage of the lipophilic active agent through the urethral membrane, and (iii) selected from the group consisting of fat-free ointments, fat-free creams and macrogols; and

(b) the lipophilic active agent comprises a vasoactive prostaglandin of a type and at a concentration effective to produce penile erection following administration of the composition to the urethra of a male individual.

21. The composition of claim 20, wherein the lipophilic active agent is selected from the group consisting of prostaglandin E.sub.1, prostaglandin E.sub.2, prostaglandin F.sub.2, and combinations thereof.

22. The composition of claim 21, wherein the lipophilic active agent is prostaglandin E.sub.1.

23. The composition of claim 21, wherein the lipophilic active agent is prostaglandin E.sub.2.

24. The composition of claim 21, wherein the lipophilic active agent is prostaglandin F.sub.2.

25. The composition of claim 21, wherein the lipophilic active agent comprises a mixture of prostaglandin E.sub.1 and prostaglandin E.sub.2.

26. The composition of claim 20, wherein the hydrophilic vehicle comprises a fat-free cream.

27. The composition of claim 20, wherein the hydrophilic vehicle comprises a fat-free ointment.

28. The composition of claim 20, wherein the hydrophilic vehicle comprises a macrogol.

29. The composition of claim 20, further comprising an additional active agent selected from the group consisting of .alpha.-blockers, vasoactive intestinal polypeptide and nitroglycerine.

30. The composition of claim 29, wherein the additional active agent is an .alpha.-blocker.

31. The composition of claim 30, wherein the .alpha.-blocker is selected from the group consisting of phentolamine, phenoxybenzamine, prazosin, and combinations thereof.

32. The composition of claim 31, wherein the .alpha.-blocker is phentolamine.

33. The composition of claim 31, wherein the .alpha.-blocker is phenoxybenzamine.

34. The composition of claim 31, wherein the .alpha.-blocker is prazosin.

35. The composition of claim 20, wherein the composition further comprises an antibacterial agent.

36. The composition of claim 20, wherein the vehicle is selected to facilitate urethral administration of the composition via instillation.
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