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|Title:||Oral dosage form for treating migraine|
|Abstract:||A pharmaceutical composition for oral adminstration comprising a film-coated solid dosage form including 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide or a pharmaceutically acceptable salt or solvate thereof as active ingredient. The film-coated solid dosage forms are of use in the treatment of conditions associated with cephalic pain, in particular migraine.|
|Inventor(s):||Phillips; Anthony John (Ware, GB3), Winterborn; Ian Keith (Mississauga, CA), Padfield; John Malcolm (Uxbridge, GB3)|
|Assignee:||Glaxo Group Limited (Greenford, GB2)|
1. A pharmaceutical composition for oral administration comprising a compressed film-coated tablet comprising a tablet core containing 25 to 200 mg of
3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide succinate (1:1) salt as active ingredient, and a pharmaceutically acceptable carrier or excipient and a film coating on said table core wherein the film coating is applied to the tablet
core in an amount of from 2 to 5% w/w of the tablet.
2. A pharmaceutical composition as claimed in claim 1 in the form of a compression tablet.
3. A pharmaceutical composition as claimed in claim 1 wherein the film coating comprises a polymer.
4. A pharmaceutical composition as claimed in claim 3 wherein the polymer is hydroxypropyl methylcellulose.
5. A pharmaceutical composition as claimed in claim 1 wherein the composition comprises 50 to 100 mg of active ingredient.
6. A method of treating a man suffering from migraine which comprises administering the composition of claim 1 to the man.
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