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Claims for Patent: 5,859,038

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Claims for Patent: 5,859,038

Title: Method for treatment of helicobacter pylori infections
Abstract:The present invention relates to a method for treating helicobacter pylori bacteria or for preventing troubles or diseases or infections due to helicobacter pylori bacteria, said method comprising administering to a subject an effective amount of a compound selected in the group consisting of: compound A of formula ##STR1## compound B of formula ##STR2## and mixture of said compounds A and B.
Inventor(s): Rossignol; Jean-Fran.cedilla.ois (Clearwater, FL)
Assignee: Romark Laboratories, L.C. (Tampa, FL)
Application Number:08/644,153
Patent Claims: 1. A method for treating helicobacter pylori bacteria comprising administering to a subject in need of treatment an effective amount of a compound selected from the group consisting of:

compound A of formula ##STR7## compound B of formula ##STR8## and a mixture of said compounds A and B.

2. The method of claim 1 comprising administering to a subject in need of treatment an effective amount of the compound A.

3. The method of claim 1 comprising administering to a subject in need of treatment an effective amount of the compound B.

4. The method of claim 1 comprising administering to a subject in need of treatment an effective amount of a mixture of compound A and compound B.

5. The method of claim 1 comprising administering to a subject in need of treatment an effective amount of a mixture of compound A and compound B, wherein the weight content of compound A with respect to the weight of said compounds A and B is greater than 99%.

6. The method of claim 1 comprising administering to a subject in need of treatment an effective amount of a mixture of compound A and compound B, wherein the weight content of compound A with respect to the weight of said compounds A and B is less than 80%.

7. The method of claim 1 comprising administering to a subject in need of treatment an effective amount of a mixture of compound A and compound B, wherein the weight content of compound A with respect to the weight of said compounds A and B is from 25% to 75%.

8. The method of claim 1, comprising administering to a subject in need of treatment an effective amount of a compound selected from the group consisting of:

compound A of formula ##STR9## compound B of formula ##STR10## and a mixture of said compounds A and B, prior to administering to the subject a compound selected from the group consisting of metronidazole, ciproflaxin, amoxicillin, amoxicillin-clavulanic acid, piperacillin, cefoxitin, imipenem and clindamycin.

9. The method of claim 1, comprising administering to a subject in need of treatment an effective amount of a compound selected from the group consisting of:

compound A of formula ##STR11## compound B of formula ##STR12## and a mixture of said compounds A and B, after administering to the subject a compound selected from the group consisting of metronidazole, ciproflaxin, amoxicillin, amoxicillin-clavulanic acid, piperacillin, cefoxitin, imipenem and clindamycin.

10. The method of claim 1, comprising administering to a subject in need of treatment an effective amount of a compound selected from the group consisting of

compound A of formula ##STR13## compound B of formula ##STR14## and a mixture of said compounds A and B, together with a compound selected from the group consisting of metronidazole, ciproflaxin, amoxicillin, amoxicillin-clavulanic acid, piperacillin, cefoxitin, imipenem and clindamycin.

11. A method for preventing infections caused by helicobacter pylori bacteria comprising administering to a subject an effective amount of a compound selected from the group consisting of:

compound A of formula ##STR15## compound B of formula ##STR16## and a mixture of said compounds A and B.

12. The method of claim 11 comprising administering to a subject an effective amount of the compound A.

13. The method of claim 11 comprising administering to a subject an effective amount of the compound B.

14. The method of claim 11 comprising administering to a subject an effective amount of a mixture of compound A and compound B.

15. The method of claim 11 comprising administering to a subject an effective amount of a mixture of compound A and compound B, wherein the weight content of compound A with respect to the weight of said compounds A and B is greater than 99%.

16. The method of claim 11 comprising administering to a subject an effective amount of a mixture of compound A and compound B, wherein the weight content of compound A with respect to the weight of said compounds A and B is less than 80%.

17. The method of claim 11 comprising administering to a subject an effective amount of a mixture of compound A and compound B, wherein the weight content of compound A with respect to the weight of said compounds A and B is from 25% to 75%.

18. The method of claim 11, comprising administering to a subject an effective amount of a compound selected from the group consisting of:

compound A of formula ##STR17## compound B of formula ##STR18## and a mixture of said compounds A and B, and an amount of a compound selected from the group consisting of metronidazole, ciproflaxin, amoxicillin, amoxicillin-clavulanic acid, piperacillin, cefoxitin, imipenem and clindamycin.
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