.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 5,846,519

« Back to Dashboard

Claims for Patent: 5,846,519

Title: Method for imaging mammalian tissue using 1-substituted-1,4,7-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
Abstract:A method for imaging mammalian tissue utilizing a non-ionic complex of a paramagnetic ion of lanthanide element and a macrocyclic chelating agent.
Inventor(s): Tweedle; Michael F. (Princeton, NJ), Gaughan; Glen T. (Oxford, GB2), Hagan; James J. (Holmdel, NJ)
Assignee: Bracco Diagnostics Inc. (Princeton, NJ)
Application Number:08/471,591
Patent Claims: 1. A complex for imaging mammalian tissue, comprising a paramagnetic ion and a tetraazacyclo compound, the complex being charge neutral in aqueous solution.

2. The complex of claim 1, wherein the Keq (M.sup.-1) (25.degree. C.; aqueous solution) for the complex is over 20.

3. The complex of claim 1, wherein the Keq (M.sup.-1) (25.degree. C.; aqueous solution) for the complex is over 23.

4. The complex of claim 1, wherein the aqueous conductivity for the complex (mho.cm.sup.2.mmol.sup.-1, 25.degree. C.) is less than 10.

5. The complex of claim 1, wherein the aqueous conductivity for the complex (mho.cm.sup.2.mmol.sup.-1, 25.degree. C.) is less than 2.

6. The complex of claim 1, wherein the osmolality of the complex (Osmol/kg water, 37.degree. C.) in a 0.5M aqueous solution is less than 1.

7. The complex of claim 1, wherein the osmolality of the complex (Osmol/kg water, 37.degree. C.) in a 0.5M aqueous solution is less than 0.65.

8. The complex of claim 1 that is bonded to a biologically active entity.

9. The complex of claim 8 wherein the biologically active entity is selected from the group consisting of bile acids, fatty acids, lipids, sugars and other alcohols, amino acids, peptides, and monoclonal antibodies and other proteins.

10. The complex of claim 1, wherein the complex in aqueous solution is stable, dissolved and the complex remains in solution when in a concentration of over 0.5M at 20.degree.-37.degree. C.

11. The complex of claim 1, wherein the complex in aqueous solution is stable, dissolved and the complex remains in solution when in a concentration of over 0.75M at 20.degree.-37.degree. C.

12. The complex of claim 1 wherein the tetraazacyclo compound is 1-substituted-1,4,7-tricarboxymethyl-1,4,7,10-tetraazaccyclododecane.

13. The complex of claim 1 wherein the complex in aqueous solution at a concentration of 0.5M has a falling ball viscosity of less than 1.5 poise at 25.degree. C.

14. A complex used for imaging mammalian tissue, comprising a metal ion selected from the group consisting of a stable isotope of the lanthanides, tantalum, bismuth or other element with a molecular weight higher than iodine, and a tetraazacyclo compound, the complex being charge neutral in aqueous solution.

15. The complex of claim 14, wherein the aqueous conductivity for the complex (mho.cm.sup.2.mmol.sup.-1, 25.degree. C.) is less than 10.

16. The complex of claim 14, wherein the osmolality of the complex (Osmol/kg water, 37.degree. C.) in a 0.5M aqueous solution is less than 1.

17. The complex of claim 14, wherein the complex in aqueous solution is stable, dissolved and the complex remains in solution when in a concentration of over 0.5M at 20.degree.-37.degree. C.

18. The complex of claim 14 wherein the tetraazacyclo compound is 1-substituted-1,4,7-tricarboxymethyl-1,4,7,10-tetraazacyclododecane.

19. The complex of claim 14 wherein the complex in aqueous solution at a concentration of 0.5M has a falling ball viscosity of less than 1.5 poise at 25.degree. C.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc