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Claims for Patent: 5,840,754

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Claims for Patent: 5,840,754

Title: Dosage form comprising oxybutynin
Abstract:A composition comprising oxybutynin, a device comprising oxybutynin, and a method for administering oxybutynin are disclosed for oxybutynin therapy.
Inventor(s): Guittard; George V. (Cupertino, CA), Jao; Francisco (San Jose, CA), Marks; Susan M. (San Jose, CA), Kidney; David J. (Palo Alto, CA), Gumucio; Fernando (Santa Clara, CA)
Assignee: ALZA Corporation (Palo Alto, CA)
Application Number:08/706,576
Patent Claims: 1. A method for lessening the incidence of side-effects in a patient associated with the oral administration of a controlled-release dosage form tablet comprising oxybutynin, wherein the method comprises administering said oxybutynin from the controlled-release dosage form tablet to the patient over twenty-four hours and thereby lessening the incidence of side effects.

2. A method for lessening side-effects and for avoiding peak concentrations of oxybutynin in the plasma in a patient by administering a dosage form tablet comprising oxybutynin, wherein the method comprises administering orally said dosage form tablet that administers oxybutynin in a controlled rate over twenty-four hours to the patient, and thereby lessens side effects and avoids peak concentrations of oxybutynin in the plasma of the patient.

3. A method for providing a continuous plasma oxybutynin concentration in a patient, wherein the method comprises administering orally a dosage form tablet comprising oxybutynin that is administered over twenty-four hours to the patient at a controlled and sustained rate to provide the desired plasma oxybutynin concentration.

4. A method for reducing peak plasma concentrations of oxybutynin administered for treating incontinence in a patient; wherein the method comprises administering a controlled-release dosage form tablet comprising oxybutynin orally to the patient over twenty four hours from the controlled-release dosage form tablet and thereby reduce peak plasma concentrations and treat the incontinence.

5. A method for governing the plasma concentrations of oxybutynin in a patient, wherein the method comprises administering orally a controlled-release dosage form tablet comprising oxybutynin that is administered from said controlled-release dosage form tablet over twenty-four hours to the patient to provide a plasma oxybutynin concentration of 4.2 to 6.7 ng/ml.

6. A method for reducing the concentration of desethyl-metabolite of oxybutynin in the plasma of a patient, wherein the method comprises administering orally to the patient oxybutynin from a controlled-release dosage form tablet over twenty-four hours and thereby reduce the concentration of the metabolite.
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