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Claims for Patent: 5,840,722

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Claims for Patent: 5,840,722

Title: Use of carboxylic acid derivatives as drugs
Abstract:A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I ##STR1##
Inventor(s): Baumann; Ernst (Dudenhofen, DE), Vogelbacher; Uwe Josef (Ludwigshafen, DE), Rheinheimer; Joachim (Ludwigshafen, DE), Klinge; Dagmar (Heidelberg, DE), Riechers; Hartmut (Ludwigshafen, DE), Kroger; Burkhard (Limburgerhof, DE), Bialojan; Siegfried (Oftersheim, DE), Bollschweiler; Claus (Heidelberg, DE), Wernet; Wolfgang (Hassloch, DE), Unger; Liliane (Ludwigshafen, DE), Raschack; Manfred (Weisenheim, DE)
Assignee: BASF Aktiengesellschaft (Ludwigshafen, DE)
Application Number:08/718,377
Patent Claims: 1. A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I ##STR16## where R is formyl, CO.sub.2 H or a radical which can be hydrolyzed to COOH, and the remaining substituents have the following meanings:

R.sup.2 is halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy or C.sub.1 -C.sub.4 -alkylthio;

X is nitrogen or CR.sup.14 where R.sup.14 is hydrogen or, together with R.sup.3, forms a 3- or 4-membered alkylene or alkenylene chain in which, in each case, one methylene group is replaced by oxygen;

R.sup.3 is halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio or R.sup.3 is linked to R.sup.14 as indicated above to form a 5- or .sup.6 -membered ring;

R.sup.4 is C.sub.1 -C.sub.10 -alkyl which can carry from one to five halogen atoms and/or one of the following radicals: C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, cyano, C.sub.1 -C.sub.8 -alkylcarbonyl, C.sub.1 -C.sub.8 -alkoxy-carbonyl, phenyl, phenoxy or phenylcarbonyl, where the phenyl radicals in turn can carry from one to five halogen atoms and/or from one to three of the following radicals: C.sub.1 -C.sub.4 -alkyl, C1-C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C1-C.sub.4 -haloalkoxy and/or C.sub.1 -C.sub.4 -alkylthio; C.sub.1 -C.sub.4 -alkyl which can carry from one to five halogen atoms and carries one of the following radicals: a five-membered heteroaromatic ring which contains from one to three nitrogen atoms and/or one sulfur or oxygen atom and which can carry from one to four halogen atoms and/or one or two of the following radicals: C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy,

C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio and/or phenyl; C.sub.3 -C.sub.12 -Cycloalkyl or C.sub.3 -C.sub.12 -cycloalkenyl, each of which can contain one oxygen or sulfur atom and can carry from one to five halogen atoms and/or one of the following radicals: C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, cyano, C.sub.1 -C.sub.8 -alkyl-carbonyl, carbonyl, C.sub.1 -C.sub.8 -alkoxycarbonyl, phenyl, phenoxy or phenyl-carbonyl, where the phenyl radicals in turn can carry from one to five halogen atoms and/or from one to three of the following radicals: C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy,

C.sub.1 -C.sub.4 -haloalkoxy and/or C.sub.1 -C.sub.4 -alkylthio; C.sub.3 -C.sub.8 -alkenyl or C.sub.3 C.sub.6 -alkynyl, each of which can carry from one to five halogen atoms and/or one of the following radicals; C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, cyano, C.sub.1 -C.sub.8 -alkylcarbonyl, C.sub.1 -C.sub.8 -alkoxycarbonyl, phenyl, phenoxy or phenylcarbonyl, where the phenyl radicals in turn can carry from one to five halogen atoms and/or from one to three of the following radicals: C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy and/or C.sub.1 -C.sub.4 -alkylthio;

a five- or six-membered heteroaromatic ring which contains from one to three nitrogen atoms and/or one sulfur or oxygen atom and which can carry from one to four halogen atoms and/or one or two of the following radicals: C.sub.1 -C.sub.4 -alkyl, C.sub.14 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, CL-c.sub.4 -alkylthio, phenyl, phenoxy or phenylcarbonyl, where the phenyl radicals in turn can carry from one to five halogen atoms and/or from one to three of the following radicals: C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C1-C.sub.4 -haloalkoxy and/or C.sub.1 -C.sub.4 -alkylthio; phenyl or naphthyl, each of which can be substituted by one or more of the following radicals: halogen, nitro, cyano, hydroxyl, C.sub.1 -C.sub.4 -alkyl, C.sub.1 --C.sub.4 -haloalkyl, C.sub.1 -.sub.4 -alkoxy,

C.sub.1 -C.sub.4 -haloalkoxy, phenoxy, C.sub.1 -C.sub.4 -alkylthio, amino C.sub.1 -C.sub.4 -alkylamino or C.sub.1 -C.sub.4 -dialkylamino; R.sup.4 and R.sub.5 form, together with the adjacent carbon atom, a 3-membered membered ring which can contain one oxygen or sulfur atom and can carry from one to three of the following radicals: C.sub.1 -C.sub.4 -alkyl, halogen, C.sub.1 -.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy and/or C.sub.1 -C.sub.4 -akylthio;

is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.3 --alkenyl, C.sub.3 -alkynyl, C.sub.3 -C.sub.8 -Cycloalkyl, C.sub.4 -C.sub.4 -haloalkyl, C.sub.4 -C.sub.4 -alkoxyalkyl,

C.sub.1 -C.sub.4 -alkylthioalkyl, phenyl or R.sub.5 is linked to R.sup.4 as indicated above to form a 3- to 8-membered ring; R.sup.6 is C.sub.1 sufyl-alkyl, C.sub.3 --alkenyl, C.sub.3 --alkynyl or C.sub.3 -C.sub.8 -cycloalkyl, it being possible for each of these radicals to be substituted one or more times by: halogen, nitro, cyano, C.sub.1 -C.sub.4 -alkoxy, C.sub.3 -C.sub.6 -alkenyloxy, C.sub.3 --alkynyloxy, C.sub.1 -C.sub.4 -alkyl-thio, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylcarbonyl, C.sub.4 -alkoxy carbonyl, C.sub.1 -C.sub.4 -alkylamino , di-C.sub.1 -C.sub.4 -alkylamino, phenyl, phenoxy or phenyl which is substituted one or more times, e.g. from one to three times, by halogen, nitro, cyano, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.4 -haloalkoxy or C.sub.1 -C.sub.4 -alkylthio;

phenyl or naphthyl, each of which can be substituted by one or more of the following radicals: halogen, nitro, cyano, hydroxyl, amino, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, phenoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -alkylamino or C.sub.1 -C.sub.4 -dialkylamino;

a five- or six-membered heteroaromatic ring which contains from one to three nitrogen atoms and/or one sulfur or oxygen atom and which can carry from one to four halogen atoms and/or one or two of the following radicals: C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkyl thio, phenyl, phenoxy or phenylcarbonyl, where the phenyl radicals in turn can carry from one to five halogen atoms and/or from one to three of the following radicals: C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy and/or C.sub.1 -C.sub.4 -alkylthio; Y is sulfur or oxygen or a single bond; Z is sulfur or oxygen.
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