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Claims for Patent: 5,837,699

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Claims for Patent: 5,837,699

Title: Use of mometasone furoate for treating upper airway passage diseases
Abstract:The administration of aerosolize particles of mometasone furoate in the form of dry powders, solutions, or aqueous suspension for treating corticosteroid-responsive diseases of the surfaces of upper and/or lower airway passages and/or lungs, e.g., allergic rhinitis and asthma is disclosed.
Inventor(s): Sequeira; Joel A. (Scotch Plains, NJ), Cuss; Francis M. (Basking Ridge, NJ), Nolop; Keith B. (Millburn, NJ), Chaudry; Imtiaz A. (North Caldwell, NJ), Nagabhushan; Nagamani (Parsippany, NJ), Patrick; James E. (Belle Meade, NJ), Cayen; Mitchell (Bedminster, NJ)
Assignee: Schering Corporation (Kenilworth, NJ)
Application Number:08/821,135
Patent Claims: 1. A method of treating a corticosteroid-responsive disease of the upper airway passages in patients afflicted with said disease, which comprises administering once-a-day to the surfaces of said passages of said patients a substantially non-systematically bioavailable amount of aerosolized particles of mometasone furoate effective for treating said disease.

2. The method of claim 1 wherein the disease is allergic or nonallergic rhinitis of the upper airway passages.

3. A method of treating a corticosteroid-responsive disease of the upper airway passages in a patient afflicted with such disease, comprising administering once daily to surfaces of said passages a non-systemically bioavailable amount ranging from about 25 to about 1600 micrograms of aerosolized particles of mometasone furoate.

4. The method of claim 3, wherein said amount of mometasone furoate ranges from about 25 to about 800 micrograms.

5. The method of claim 3, wherein said amount of mometasone furoate ranges from about 25 to about 400 micrograms.

6. The method of claim 3, wherein said amount of mometasone furoate ranges from about 25 to about 200 micrograms.

7. The method of claim 3, wherein said amount of mometasone furoate ranges from about 25 to about 100 micrograms.

8. The method of claim 3, wherein said amount of mometasone furoate is about 100, 200 or 400 micrograms.

9. A method of treating a corticosteroid-responsive disease of the upper airway passages in a patient afflicted with said disease, which comprises the step of administering daily a non-systematically bioavailable amount of mometasone furoate ranging from about 10 to about 800 micrograms, in the form of aerosolized particles, to the surfaces of said passages of said patient.

10. The method according to claim 9, wherein said amount of aerosolized particles of mometasone furoate ranges from about 25 to about 400 micrograms.

11. The method according to claim 9, wherein said amount of aerosolized particles of mometasone furoate ranges from about 25 to about 200 micrograms.

12. The method according to claim 9, wherein said amount of aerosolized particles of mometasone furoate ranges from about 25 to about 100 micrograms.

13. A method of treating allergic or non-allergic rhinitis in patients afflicted with said rhinitis which comprises administering once-a-day to the surfaces of the upper airway passages of said patients an amount of aerosolized particles of momentasone furoate effective to maximize topically treating said rhinitis in the upper airway passages while simultaneously substantially minimizing systemic bioavailability thereof.

14. The method of claim 13 wherein the momentasone furoate is administered intranasally.

15. The method of claim 13 wherein the amount of mometasone furoate administered is in the range of about 25 to about 800 micrograms/day.

16. The method of claim 13 wherein the mometasone furoate is administered in the form of an aqueous suspension.

17. A dosage form useful for treating a corticosteroid-responsive disease of the upper airway passages in a patient afflicted with said disease, said dosage form comprising: a device which can contain and deliver to the surfaces of said passages of said patient, at least one daily dose of between about 10 and about 800 micrograms of aerosolized particles of mometasone furoate; and contained therein, at least one dose of between about 10 and about 800 micrograms of mometasone furoate capable of being administered to the surfaces of said upper airway passages of said patients as aerosolized particles.

18. The dosage form of claim 17, further comprising a plurality of doses of about 10 to about 800 micrograms of mometasone furoate.

19. The dosage form of claim 18, wherein at least one daily dose of mometasone furoate ranges from about 25 to about 400 micrograms.

20. The dosage form of claim 18, wherein at least one daily dose of mometasone furoate ranges from about 25 to about 200 micrograms.

21. The dosage form of claim 18, wherein at least one daily dose of mometasone furoate ranges from about 25 to about 100 micrograms.
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