|Title:||Tumor treatment with arabinofuranosyl purine derivatives|
|Abstract:||6-Alkoxy derivatives of Ara-G, and pharmaceutically acceptable esters thereof, are described as being useful in tumor therapy. Novel pharmaceutically acceptable esters, their preparation and pharmaceutical formulations containing them are also disclosed.|
|Inventor(s):||Krenitsky; Thomas Anthony (Chapel Hill, NC), Averett; Devron Randolph (Raleigh, NC), Koszalka; George Walter (Chapel Hill, NC)|
|Assignee:||Glaxo Wellcome Inc. (Research Triangle Park, NC)|
1. A method for the inhibition of susceptible tumours in a mammal which comprises administering to said mammal an effective tumour inhibiting amount of a compound of the formula (I)
##STR2## wherein R.sup.1 is a C.sub.1-5 alkoxy group or a pharmaceutically acceptable ester or salt thereof.
2. A method according to claim 1 wherein R.sup.1 is methoxy.
3. The method of claim 1, wherein said compound is selected from the group consisting of
or a pharmaceutically acceptable salt thereof.
4. The method of claim 1, wherein said compound is 2-amino-6-methoxy-9-(5-O-acetyl-.beta.-D-arabinofuranosyl)-9H-purine.
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