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Claims for Patent: 5,817,657

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Claims for Patent: 5,817,657

Title: Psychoactive substance disorders
Abstract:2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders relating to the use of psychoactive substances. The compound has the following structure: ##STR1##
Inventor(s): Beasley, Jr.; Charles M. (Indianapolis, IN), Chakrabarti; Jiban Kumar (Camberley, GB2), Hotten; Terrence Michael (Farnborough, GB2), Tupper; David Edward (Reading, GB2)
Assignee: Eli Lilly and Company (Indianapolis, IN) Eli Lilly and Company Limited (Basingstoke, GB2)
Application Number:08/748,294
Patent Claims: 1. A method for treating a patient suffering from or susceptible to a pathologic psychological condition selected from the group consisting of Alcohol Withdrawal Delirium; Alcohol Hallucinosis; Alcohol Dementia Associated with Alcoholism; Amphetamine or Similarly Acting Sympathomimetic Intoxication; Amphetamine or Similarly Acting Sympathomimetic Delirium; Amphetamine or Similarly Acting Sympathomimetic Delusional Disorder; Cannabis Delusional Disorder; Cocaine Intoxication; Cocaine Delirium; Cocaine Delusional Disorder; Hallucinogen Hallucinosis; Hallucinogen Delusional Disorder; Hallucinogen Mood Disorder; Hallucinogen Posthallucinogen Perception Disorder; Phencyclidine (PCP) or Similarly Acting Arylcyclohexylamine Intoxication; Phencyclidine (PCP) or Similarly Acting Arylcyclohexylamine Delirium; Phencyclidine (PCP) or Similarly Acting Arylcyclohexylamine Delusional Disorder; Phencyclidine (PCP) or Similarly Acting Arylcyclohexylamine Mood Disorder; Phencyclidine (PCP) or Similarly Acting Arylcyclohexylamine Organic Mental Disorder NOS; Other or Unspecified Psychoactive Substance Intoxication; Other or Unspecified Psychoactive Substance Delirium; Other or Unspecified Psychoactive Substance Dementia; Other or Unspecified Psychoactive Substance Delusional Disorder; Other or Unspecified Psychoactive Hallucinosis; Other or Unspecified Psychoactive Substance Mood Disorder; Other or Unspecified Psychoactive Substance Personality Disorder; and Other or Unspecified Psychoactive Substance Organic Mental Disorder NOS; comprising administering an effective amount of 2-methyl-4-(4-methyl-1-piperazinyl) -10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid addition salt thereof, to the patient.

2. A method of claim 1 wherein the condition is Alcohol Dementia Associated with Alcoholism; Amphetamine or Similarly Acting Sympathomimetic Intoxication; Other or Unspecified Psychoactive Substance Mood Disorder; Other or Unspecified Psychoactive Substance Personality Disorder; Other or Unspecified Psychoactive Substance Organic Mental Disorder NOS; Hallucinogen Mood Disorder; Phencyclidine (PCP) or Similarly Acting Arylcyclohexylamine Intoxication; Phencyclidine (PCP) or Similarly Acting Arylcyclohexylamine Mood Disorder; Phencyclidine (PCP) or Similarly Acting Arylcyclohexylamine Organic Mental Disorder NOS; Other or Unspecified Psychoactive Substance Intoxication, or Other or Unspecified Psychoactive Substance Dementia.

3. A method of claim 1 wherein the effective amount is from 1 to 20 mg per day.

4. A method of treating a patient suffering from or susceptible to a pathologic psychological condition selected from the group consisting of Alcohol Withdrawal Delirium; Alcohol-Induced Psychotic Disorder, With Hallucinations; Alcohol-Induced Persisting Dementia; Amphetamine Abuse; Amphetamine, Cannabis, Cocaine, Hallucinogen, Inhalant, Opioid, Phencyclidine, Sedative, Hypnotic or Anxiolytic Intoxication Delirium; Amphetamine-, cannabis-, Cocaine-, Hallucinogen-, Inhalant-, Opioid-, Phencyclidine-, Sedative-, Hypnotic-, Anxiolytic-or Other (or Unknown) Substance-Induced Psychotic Disorder; Cocaine Abuse; Hallucinogen Abuse; Amphetamine-, Cocaine-, Hallucinogen-, Inhalant-, Opioid-, Phencyclidine-, Sedative-, Hypnotic-, Anxiolytic-or Other (or Unknown) Substance-Induced Mood Disorder; Hallucinogen Persisting Perception Disorder; Phencyclidine, Inhalant or Other (or Unknown) Substance Abuse; Inhalant-, Sedative-, Hypnotic-, Anxiolytic-or Other (or Unknown) Substance-Induced Persisting Dementia; Phencyclidine-Related Disorder NOS; Other (or Unknown) Substance-Induced Delirium; Other (or Unknown) Substance Intoxication; or Other (or Unknown) Substance-Related Disorder NOS; comprising administering an effective amount of 2-methyl-4-(4-methyl-1-piperazinyl)-lOH-thieno-[2,3-b][1,5]benzodiazepine, or an acid addition salt thereof, to the patient.

5. A method of claim 4 wherein the effective amount is from 1 to 20 mg per day.
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